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Articles by K.M. Anigo
Total Records ( 3 ) for K.M. Anigo
  D.H. Mhya , K.M. Anigo , I.A. Umar and J.O. Alegbejo
  Background and Objective: Previous studies showed both leaves and stem-bark of Balanites aegyptiaca possess anti-diabetic properties however, extract from the leaves seem to be more effective. In comparison of activity between fractionated ethanol extracts; aqueous fraction (ALF) and ethyl acetate fraction (ELF) of the plant leaves, it was found that the aqueous fraction was highly effective over the ethyl acetate fraction. Guided by this, the present study subjected ALF to bio-guided fractionation where sub-fractions were validated in STZ-induced diabetic rats with the aim to ascertain whether anti-diabetic components presence could be further separated. Materials and Methods: Ethanol-aqueous fraction (ALF) of Balanites aegyptiaca leaves was fractionated by Gel Filtration Chromatograph using silica gel packed in a chromatographic column. The ALF was dissolved in distilled water and then applied unto the gel packed in a chromatographic column and eluted with solvent system of increasing polarity; diethyl ether, diethyl ether/chloroform (1:1 v/v), chloroform and methanol. The eluted sub-fractions namely: L1, L2, L3 and L4 were kept at room temperature (25°C) for the solvents to be evaporated and sub-fractions subjected to thin layer chromatography using silica gel G-coated plate. Diabetic rat groups were administered to various sub-fractions while positive control rats received metformin, normal and negative control rat groups received distilled water. Results: The yields, total phenolics and flavonoids content of sub-fractions obtained from the column fractionation of ethanol-aqueous fraction of Balanites aegyptiaca leaves showed methanol sub-fraction (L4) with highest percent yield and total phenolics content whereas diethyl ether/chloroform leaves sub-fraction (L2) was high in flavonoids content. Significant anti-hyper-glycemic effect were recorded from diabetic rat groups that received metformin and methanol leaves sub-fraction (L4) as indicative by a significant decrease in the trend of their weekly fasting blood glucose levels and values of area under fasting blood glucose curve (AUC). Diabetic rat groups that received L4 showed a significant reverse in serum lipid levels but increase in body weight comparable with diabetic rat groups treated with other sub-fractions. Water and feed intake of all diabetic treated rats were significantly different when compared with the untreated diabetic and normal control rats. Conclusion: The study suggested that bio-active compound(s) of Balanites aegyptiaca leaves is/are polar in nature and could be carefully isolated by bio-guided fractionation.
  K.M. Anigo , D.A. Ameh , S. Ibrahim and S.S. Danbauchi
  Studies on microbiological concentration of commonly used local complementary foods in three states of North Western Nigeria were carried out. Total aerobic count in complementary foods from Kaduna state was greater than the 104 permissible limits. Unacceptable levels of Salmonella and Shigella were detected in some of the samples. Results also indicated the predominance of Staphylococcus sp. and fungi and molds, which showed that the levels of contamination of some of the samples are very high when compared to International Standards. Attention needs to be paid to the specific behaviours surrounding feeding and any constraints to care as important interventions in order to improve feeding practices in Northern Western Nigeria.
  M.A. Abdulazeez , A.I. Busari , S. Yakubu , K.M. Anigo , H.O. Idris and A. Salihu
  To determine the prevalence of hypertension and impaired renal function in diabetic patients attending Ahmadu Bello University Teaching Hospital, Zaria, Kaduna State, Nigeria. Two hundred subjects (one hundred and twenty diabetic and eighty control subjects) attending the diabetic clinic of the hospital were evaluated between the months of May and June, 2012. From the results, the prevalence of hypertension among diabetic patients attending the hospital was 78.33%. A total of 63.33% of the patients have type II diabetes mellitus, while 36.67% had type I. The urea, potassium, bicarbonate and glucose levels were normal and creatinine (58.33%) and sodium (88.1%) levels were abnormal in most patients. The result shows that 80% of female patients between 50 to 59 years were hypertensive, while 40% of the males within the same age range were also hypertensive. Also, 30% of unemployed diabetic patients attending the hospital were hypertensive, while none of the control subjects were hypertensive. Most of the diabetic patients (40%) were primary school certificate holders, while 2.5% of the patients had a post graduate degree. In conclusion, the high prevalence of hypertension and renal impairment are public health challenges and so educational programs on monitoring of blood sugar and screening of risk factors for hypertension, early diagnosis and treatment of hypertension should be given periodically.
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