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| Articles
by
K.I. Mohammed |
Total Records (
2 ) for
K.I. Mohammed |
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S.M. Mosaad
,
K.I. Mohammed
,
M.A. Ahmed
and
S.G. Abdel-Hamide
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A series of 2-(4-chlorophenyl)-6-iodoquinazoline carrying different acyclic or heterocyclic moieties were prepared and tested for their activity against certain strains of Gram negative bacteria, Gram positive bacteria and pathogenic Fungi. The results revealed that some of synthesized compounds displayed marked activity against some of the tested microorganisms |
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S.M. Mosaad
,
K.I. Mohammed
,
M.A. Ahmed
and
S.G. Abdel-Hamide
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A new series of anthranilic acid derivatives were prepared through reaction of
2-(4-chlorophenyl)-6-iodo-4(H)-3,1-benzoxazine 3 with some amines. Reaction
of {2-(4-chlorophenyl)-3-amino-6-iodo-3,4-dihydro-quinazolin-4-one} 6 and {2-(4-chlorobenzoyl-amino)-5-iodobenzoic
acid hydrazide} 7 with some aldehydes and acid anhydrides was also reported. The
structures of the new compounds were confirmed by microanalyses and spectral data.
Some compounds showed promising antibacterial activities against Staphylococcus
aureus and Bacillus Subtillis. Compounds 5h and 5K showed the highest
activity (MIC = 12.5 μg ml-1), compound 12 a (MIC = 20.0 μg ml-1),
compounds 5 a-g, 5 I, 5 j, 6 r, 9 a-h, (MIC = 50 μg ml-1) and
compounds 8 g, 12 b, 12 c, (MIC = 100 μg ml-1). |
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