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Articles by K.H.S. Farvin
Total Records ( 2 ) for K.H.S. Farvin
  K.H.S. Farvin , A. Surendraraj and R. Anandan
  In the present study an attempt has been made to assess the cardioprotective effect of squalene on isoprenaline-induced myocardial infarction in male albino rats with respect to changes in the levels of endogenous antioxidant vitamins in heart tissue. Levels of endogenous antioxidants such as ascorbic acid, α-tocopherol and endogenous squalene content in heart tissue were determined. Significant (p<0.001) reduction was observed in the levels of ascorbic acid, α-tocopherol and endogenous squalene content in the heart tissue of isoprenaline administered rats compared to normal control rats. It is worth noting that, the prior administration of squalene at 2% level along with feed for 45 days significantly (p<0.001) reduced the isoprenaline-induced decline in the levels of these vitamins and restored the membrane bound squalene content at near normal. The results of the present study indicates that the cardioprotective effect of squalene might be ascribable to its antioxidant property thereby sharing the responsibility of these antioxidant vitamins in counteraction of free radicals generated during isoprenaline-induced oxidative stress.
  K.H.S. Farvin , A. Surendraraj and R. Anandan
  This study was aimed to evaluate the preventive role of squalene on free amino acids and lysosomal alterations in experimentally induced myocardial infarction in rats. The levels of lysosomal enzymes (β-glucuronidase, β-galactosidase, β-glucosidase, acid phosphatase and cathepsin D) in plasma and lysosomal fractions, hydroxyproline content and free amino acids in heart tissue were determined. Isoprenaline administration to rats resulted in decreased stability of the membranes which was reflected by significantly (p<0.001) lowered activity of β-glucuronidase, β-galactosidase, β-glucosidase, acid phosphatase and cathepsin D in the lysosomal fraction with a concomitant increase in plasma. Significant (p<0.001) reduction was also observed in the levels of taurine and hydroxyproline with a concomitant increase in the levels of aspartate, glutamate and arginine in the heart tissue of isoprenaline administered rats compared to normal control rats. Pretreatment with squalene at 2% level along with feed for 45 days significantly (p<0.001) prevented these alterations in free amino acids, hydroxyproline and lysosomal hydrolases and maintained the rats at near normal. Thus, the results of this present study show that squalene protects the lysosomal membrane against isoprenaline induced oxidative stress. The overall cardioprotective effect of squalene is ascribable to its ability to strengthen myocardial membrane including lysosomal membrane by its membrane stabilizing action and consequent diminution in the liberation of hydrolytic enzymes or by counteraction of free radicals by its antioxidant nature.
 
 
 
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