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Articles by K.A.R. Suzainur
Total Records ( 5 ) for K.A.R. Suzainur
  Mahmood A.A. , K. Sidik , I. Salmah , K.A.R. Suzainur and K. Philip
  The aqueous extract of Ageratum conyzoides leaves was evaluation for their cytoprotective activity against ethanol-induced gastric lesions in rats. Four groups of male Sprague Dawley rats each consist of 6 animals. Group I animals were pretreated with phosphate buffer saline 5 mL kg 1 as a control, where as Group II and Group III rats were pretreated with 250 mg kg 1 and 500 mg kg 1 Ageratum conyzoides extract (5 mL kg 1), respectively. Group IV rats were pretreated with cimetidine 50 mg kg 1 as reference. After 30 min all animals were administered absolute ethanol 5 mL kg 1 orally and 15 min later all rats were sacrificed. Macroscopically, oral administration of absolute ethanol to rats pretreated with PBS significantly produced extensive hemorrhagic lesions of gastric mucosa, whereas animals pretreated with 250 mg kg 1 and 500 mg kg 1 aqueous extract or cimetidine significantly reduced the formation of gastric lesions compared to control group. Microscopically, pretreated rats with aqueous extract or cimetidine showed significantly marked inhibition of gastric lesions and marked reduction of submucosal edema compared to control group. These results strongly document the beneficial cytoprotective effects of plant extract against ethanol-induced gastric ulcer in rats.
  A.A. Mahmood , K. Sidik , I. Salmah and K.A.R. Suzainur
  Two groups of Sprague-Dawley adult male rats each consist of 8 animals were used throughout the experiment. All rats were subcutaneous inoculated once with 108cfu/ml of Pasteurella multocida strain PMB 202. In addition, Group 1 animals also received intra-muscular injection of dexamethasone (1.6 mg/animal/day) once daily for 9 days. Blood was collected from all animals before and after inoculation once daily for 9 days, for total and differential leucocytes count. Rats were scarified at day 9 for swabs culture and histological sections of liver, spleen and lung. In dexamethasone-treated animals (Group 1), total leucocytes count decreased after 24 hours (day 1) post-infection and then leucocytosis at day 4 (96 h), then leucopenia at day 8 and 9. Differential leucocytes count revealed gradual neutrophilia and lymphopenia at 120 h post infection (maximum), then neutropenia and lymphocytosis at day 7 and 9. Swab cultured from liver, spleen, and lung revealed positive for P. multocida and Staphylococcus aureus. Histological sections of such organs showed abscess formation surrounded by neutrophils. In Pasteurella multocida inoculated animals (Group 2), total leucocytes count started to increase gradually at day 1 and 2, then decreased to normal level at day 3 and leucocytosis at day 4 (maximum) and then gradual decreased to reach the normal level at day 9. Differential leucocytes count revealed, neutropenia and lymphocytosis at 24 hour post infection, and remain with the same level reaching maximun at day 9 with atypical lymphocytes. Swab cultured from liver, spleen and lungs showed negative for bacterial isolation. Histological sections of such organs reveled erythrocyte infiltration and mild infiltration of inflammatory cells.
  Salmah , A.A. Mahmood , K. Sidik , M. H. M. Nazmul and K.A.R. Suzainur
  Eight plant species were picked randomly and their aqueous extracts have been screened to know their effects on the phagocytic capability and intracellular killing of E. coli bacteria by rat peritoneal macrophages. Macrophage cultures were incubated with different concentration of each plant extract for 1 hour. Among these aqueoud extracts, Ageratum conyzoides and Malastoma melabathricum inhibited the phagocytic capability and intracellular killing of E. coli compared with controls. Elicited (activated) cells have more phagocytic capability and intracellular killing than the resident (normal) macrophages. There were no differences in the viability of cells between treated cells with extract and controls.
  A.A. Mahmood , K. Sidik , I. Salmah , K.A.R. Suzainur and K.M. Yusoff
  The gastroprotective effects of honey and methanol extract of P. granatum L. fruit peel and N. sativa L seeds were investigated in the rat against ethanol-induced gastric damage. 5 groups of adult Sprague-Dawley rats were used throughout the experiment. Oral administration of absolute ethanol (5 ml kg-1 body weight) to fasted rats produced extensive lesions of gastric mucosa (Group 2). Pretreatment with honey (2.5 g kg-1 body weight) alone (Group 3) or honey in combination with each of P. granatum L. (0.1 g kg-1) (Group 4) or N. sativa L. (0.1 g kg-1) extracts (Group 5) orally 30 min before administration of absolute ethanol (5 ml kg-1) decreased or prevented the formation of such lesion. The observed protection was more pronounced when honey combined with each extract than honey alone. Honey in combination with N sativa L. completely ablated gastric lesions. Although the mechanism of gastric cytoprotection is unknown, honey in combination with each plant extracts appears to increase the resistance of gastric mucosal cells to the necrotizing effect of strong irritants (absolute alcohol). These results suggest that honey in combination with N. sativa L. or P. granatum L. extracts maintain the cellular integrity of the gastric mucosa, and might be beneficial in the treatment of a variety of diseases in which gastric mucosal injury is present.
  Salmah, A.A. Mahmood , K. Sidik , M.H.M. Nazmul , K.A.R. Suzainur and M. Indran
  The present work was done to investigate the possible effects of honey alone or in combination with each of Nicotiana tabacum L. leaves or Punica granatum L. fruit shells on the rate of wound healing process and on the rate of wound infection in rats. Three groups of adult male Sprague Dawley rats each group consist of six animals. All animals were experimentally wounded in the posterior neck area. Pure unboiled honey was applied topically to Group 1, whereas honey in combination with each of N. tabacum L. or P. granatum L. were used for dressing of group 2 and group 3, respectively. Wounds treated with honey in combination with each N. tabacum L. or P. granatum L. healed significantly (P<0.05) earlier than that treated with honey alone. All wounds showed clean and remain sterile until complete healing. These results strongly document the beneficial effects of honey in combination with each of N. tabacum L. or P. granatum L. for the acceleration of wound healing process, minimal scar formation and the rates of wounds sterility.
 
 
 
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