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Articles by K.A.N. Esievo
Total Records ( 3 ) for K.A.N. Esievo
  C. Uchendu , S.F. Ambali , J.O. Ayo , K.A.N. Esievo , I.O. Lasisi and Y.L. Surakat
  Induction of oxidative stress is one of the molecular mechanisms involved in chlorpyrifos-induced toxicity. The study was aimed at evaluating the effect of Acetyl-L-Carnitine (ALC), an antioxidant molecule on alterations in biochemical changes evoked by subacute chlorpyrifos (CPF) exposure in Wistar rats. Twenty-eight young adult male Wistar rats used for the study were divided into 4 groups of 7 animals each. Group I was administered S/oil (2 mL kg-1) while group II was given ALC (300 mg kg-1). Group III was administered CPF (8.5 mg kg-1) while group IV was pretreated with ALC (300 mg kg-1) and then administered CPF (8.5 mg kg-1), 30 min later. The regimens were administered orally via gavage for 4 weeks. The sera obtained from the blood samples were analysed for concentrations of electrolytes (Na+, K+, Cl¯ and HCO3¯), total proteins, albumin, globulin glucose, urea, creatinine and activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and creatine kinase. The liver was also examined for malonaldehyde concentration and activities of superoxide dismutase and catalase. The result shows that ALC pretreatments attenuate CPF-evoked alterations in biochemical parameters apparently due to its antioxidant properties.
  S.F. Ambali , M. Mamman , A.O. Adaudi , K.A.N. Esievo , N.D.G. Ibrahim and M.S. Abubakar

Mushrooms are macrofungi widely consumed as food. However, many mushrooms rot away in the wild because of fear of toxicity. Therefore, lyophilized aqueous extracts of 6 mushroom species collected from Zaria, Nigeria and taxonomically identified as Chlorophyllum molybdites, Panaeolus subalteatus, Macrolepiota procera, Leucopaxillus albissmus, Hygrophoropsis aurantiacus and Pholiota aurea were screened for toxicity in mice. Lyophilized aqueous extract of each of these mushrooms was administered to three groups of 3 mice intraperitoneally (i.p.) at doses of 100, 1000 and 10, 000 mg kg-1, respectively. Another group of three mice given distilled water served as control. The mice were examined for clinical signs of toxicity over a period of 72 h and pathological examinations conducted on dead animals. The severity of clinical signs, onset of death and pathological lesions were dose dependent. Death occurred within 10 min in all the mice dosed at 10,000 mg kg-1 with the lyophilized extracts of all the mushrooms screened, with the exception of that of H. aurantiacus, which produced death 21-23 h post administration. This result showed that all the screened mushrooms, including the popular edible M. procera were found toxic. Therefore, since all the mushrooms screened were found toxic, it is recommended that extreme caution should be exercised in their consumption. Furthermore, in view of the regional differences in the toxicity of mushrooms, there is the need to screen more wild mushrooms found in Nigeria for toxicity. This will boost mushroom mycophagy, reduce poisoning incidence and reduce wastage of edible mushrooms in the wild.

  J.S. Neils , A.K. BSackey , U.S. Abdullahi and K.A.N. Esievo
  Yankassa sheep (20) were grouped into A and B and infected with Trypanosoma congolense isolated from a cow and maintained in mice. Two milliliterx107 parasites were used to infect group A. The course of the infection and serum trace minerals (Iron, (Fe) and Copper, (Cu) were studied and determined using Atomic Absorption Spectrophotometer (AAS). There was significant drop in concentration of iron (p<0.001) Post Infection (pi) while that of copper, no significant change (p>0.05). The values of the contemporaneously uninfected control sheep were significantly higher for iron and not for copper. Sheep are susceptible to isolate from cow and passaged in mice and with the fluctuating concentrations of Fe and consistency of Cu, it may suggest that these minerals may have a role in the pathogenesis of trypanosomosis due to T. congolense.
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