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Articles by K.A.K. Kamilah
Total Records ( 2 ) for K.A.K. Kamilah
  F.A. Khairunnuur , A. Zulkhairi , I. Hairuszah , A. Azrina , I. Nursakinah , F. Fazali , M.N.H. Kamal , M.S. Zamree and K.A.K. Kamilah
  The global prevalence of overweight and obesity has reached epidemic proportions. Hyperlipemia couple with increased oxidative stress generates various degenerative diseases such as hypertension and cardiovascular problems. In the present study, a hypolipemic and weight reducing effects of crude Tamarindus indica L. pulp extract were examined in adult Sprague-Dawley rats fed a high-fat diet. Animals were fed on either normal chow or high-fat diet for 10 weeks for obesity induction and subsequently received either placebo or T. indica L. extract at 5, 25, 50 or 300 mg kg-1 chitosan via oral gavage for another 10 weeks. Treatment of obese rats with the T. indica pulp extract led to a decrease in the levels of plasma total cholesterol (TCHOL), low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) and increase high-density lipoprotein cholesterol (HDL-C) level with concomitant reduction of body weight. The extract improved the efficiency of the antioxidant defense system, as indicated by increased superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and subsequently resulted in significantly lower lipid peroxidation indices; malondialdehyde (MDA) level. Together these results indicate the potential use of T. indica extracts as hypolipemic and antioxidative agent apart from its ability to reduce body weight in obese-induced rats.
  S.K. Ihsan , H.A. Zulkhairi , M.A. Abdah , J.A. Daryl , I. Noramalina , M.A. Rasadah , M. Shahidan , M.S. Zamree , K.A.K. Kamilah , N.H. Mohd Kamal , A. Azrina , M.E. Norhaizan , M.A.M. Aris and M.B. Taufik
  The aimed of this study was to investigate the antioxidant properties of T. crispa as well as its ability to attenuate the release of oxidant markers in induced oxidation in Human Umbilical Vein Cells (HUVECs). In vitro studies of antioxidant properties of T. crispa showed the DPPH scavenging activity of T. crispa Aqueous (TCAE) and Methanol Extract (TCME) were 82±1.78 and 73±1.01%, respectively. FRAP value of TCAE and TCME were 1.04±0.27 and 1.64±0.06 mmol L-1, respectively. Total Flavonoids Content (TFC) of TCAE and TCME were 205.58±3.5 and 223±10.49 mg QE g-1 sample, respectively while Total Phenolics Content (TPC) of TCAE and TCME were 32.58±0.68 and 41.64±0.97 mg GAE mg-1 sample, respectively. The antioxidant enzymes activities (CAT, SOD and GPx) in HUVECs treated with T. crispa extracts to counter the oxidative effect by hydrogen peroxide (H2O2) and lipid peroxidation activity by Malondialdehyde (MDA) were also measured. The result showed TCAE and TCME at a concentration ranges from 100-600 μg mL-1 significantly increased (p<0.05, 0.01) the level of CAT, SOD and GPx. Results of MDA assay showed significant reduction (p<0.05, 0.01) of MDA level in HUVECs treated with TCAE and TCME. Taken together, the findings suggest that T. crispa extracts can effectively protect HUVECs against oxidative stress by H2O2 which might be of importance in the treatment of cardiovascular diseases.
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