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Articles by K. Vasanth
Total Records ( 3 ) for K. Vasanth
  K. Vasanth and V. Jawahar Senthilkumar
  Mean of unsymmetrical trimmed variants is used as a detector for the detection of fixed valued impulse noise is proposed. A fixed 3x3 window is kept constant for the increasing noise densities. The processed pixel is considered as noisy if the absolute difference between processed pixels and mean of unsymmetrical trimmed variants is greater than fixed threshold. Under high noise densities if the processed pixel is noisy and computed median is also noisy then replace the processed pixel with mean of unsymmetrical trimmed variants else if the processed pixel is noisy and computed median is not noisy then the corrupted pixel is replaced by computed median else the pixel is termed uncorrupted and it is left unaltered. If the entire pixels of the current processing window are noisy then global mean of the image is replaced as output. The Proposed Algorithm (PA) is tested on different varying detail images. The proposed algorithm is compared with the standard algorithms and found to give good results both qualitative and quantitatively for increasing noise densities.
  G.C. Minakshi , K. Vasanth , Tanupriya , K. Ilango , Aruna Agrawal and G.P. Dubey
  Diseases caused due to ‘oxidative stress’ initiated by Reactive Oxygen Species (ROS) is growing at an alarming rate. Several medicinal herbs explored till date were reported to possess numerous pharmacological properties used for combating different diseases. The present study was undertaken to investigate the inhibitory potential of Terminalia chebula by H2O2 induced oxidative stress in THP-1 cell line and also the presence of the marker compounds in T. chebula was confirmed by High Performance Liquid Chromatography (HPLC). Intracellular quantification of ROS was done using a flow cytometer. The percentage of gallic acid and ellagic acid in the extract was performed by HPLC were found to be 4.84% w/w and 2.56% w/w, respectively. Pretreatment of cells with T. chebula extract significantly reduced the intracellular ROS production in a dose-dependent manner. The present study illustrates the effective role of T. chebula in reducing the ROS production which is a causative factor for several disorders. The results describe the possibility and potentiality of natural sources to inhibit the pathogenesis of different diseases caused due to oxidative stress.
  G.C. Minakshi , K. Vasanth , Tanupriya , K. Ilango , R. Mohan Kumar , Aruna Agrawal and G.P. Dubey
  Garcinia indica have been used for centuries with claim for its medicinal value by traditional practitioners to treat numerous diseases. The anti-oxidant activity of G. indica fruit which were assessed by determining the total phenolic content, evaluating the 2, 2-diphenyl-1-picrylhydrazyl, (DPPH) activity, superoxide dismutase (SOD) activity, as well as its ability to inhibit Nitric Oxide (NO) and also their effect on H2O2 induced Reactive Oxygen Species (ROS) generation in human monocytic (THP-1) cells was investigated by tracking intensity of a cell permeable fluorescent dye. In addition, High Performance Liquid Chromatography (HPLC) was used to quantify the bioactive constituent of G. indica fruit extract responsible for its biological activity. The fruit extract of G. indica had the highest amount of hydroxycitric acid (HCA) and phenolic content showed potent antioxidant activity. The IC50 values for DPPH, SOD and NO scavenging activities were 50.34, 37.08 and 34.15 μg mL–1, respectively. Garcinia indica fruit extract (200 μg mL–1) attenuated ≥60% of H2O2 mediated ROS generation in THP-1 cells. The above data provides evidence that the fruit extract of G. indica is rich in natural anti-oxidants and thus justify its use in folk medicine especially in the management of free radical-mediated disorders.
 
 
 
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