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Articles by K. Shaari
Total Records ( 2 ) for K. Shaari
  N.A.M. Ali , M. Rahmani , K. Shaari , A.M. Ali and G. Ee Cheng Lian
  The air dried barks of Cinnamomum impressicostatum and C. pubescens were separately and sequentially extracted with hexane, chloroform and methanol and assayed against five bacteria and four fungi by disc diffusion method. The hexane and chloroform extracts of the plants strongly suppressed the growth of the four fungi but range from moderate to weak towards bacteria. The methanol extracts only displayed weak activity on some of these organisms. Based on these results, further work was carried on bioassay-guided isolation of active extracts of C. impressicostatum and C. pubescens and on both occasions the active component was identified as (E)-methyl cinnamate. Other compounds were also isolated and identified as safrole, (E)-piperonylprop-2-enal, β-sitosterol, (E)-piperonylprop-2-enol and cinnamic acid. The structures of the compounds were established by spectroscopic method and comparison with literatures. (E)-methyl cinnamate exhibited strong growth inhibition towards four of the fungi Saccharomyces cerevisiae, Candida lipolytica, C. albicans, Microsporum canis with inhibition zone ranging from 24.5 to 19.8 mm. The compound is also capable of suppressing the growth of bacteria Bacillus cereus. It is proposed that the excellent antifungal activities of the hexane and chloroform extracts of C. impressicostatum and C. pubescens correlate with the presence of (E)-methyl cinnamate as the major component.
  R. Ahmad , H.M. Hashim , Z.M. Noor , N.H. Ismail , F. Salim , N.H. Lajis and K. Shaari
  The aim of the study was to evaluate the antioxidant and antidiabetic potential of five Malaysian Uncaria species namely U. lucida, U. acida, U. cordata, U. callophylla and U. longiflora var. pteropoda, find any correlation between these two activities and relate them to their phytochemical content. Measurement of antioxidant activities employed ferric thiocyanate (FTC), thiobarbituric (TBA) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) assays while evaluation of total phenolic contents employed Folin Ciocalteau methods. Antidiabetic potential was evaluated by α-glucosidase inhibitory assays. All tested extracts exhibited very strong antioxidant potential in the FTC and TBA assays. U. longiflora v.p. (stems and leaves) and U. calophylla (stems) exhibited strong DPPH free radical scavenging activity with IC50 values of 8-20 μg mL-1 compared to 8 μg mL-1 for vitamin C and 7 μg mL-1 BHT. In the α-glucosidase inhibitory assay, the stem extracts of the two plants showed strong α-glucosidase inhibition (>99%). The anti-diabetic activity exhibited by the two plants correlated well with its radical scavenging activities and its phytochemical content. This study has found Malaysian Uncaria to be potentially important sources of antioxidants and anti-diabetic agents, which may be used in prevention and control of type II diabetes.
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