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Articles by K. Rajesh
Total Records ( 4 ) for K. Rajesh
  K. Rajesh , K.C. Padmavathi , A. Ranjani , P.M. Gopinath , D. Dhanasekaran and G. Archunan
  The silver nanoparticles (AgNPs) were synthesized using extracellular metabolites of Streptomyces sp. GRD (JX512257). The characterization of the synthesized AgNPs was performed by UV-VIS spectrophotometer, FT-IR, Scanning Electron Microscopy (SEM) and X-ray diffraction spectroscopy. The synthesised silver nanoparticles have maximum absorption at 450 nm in UV-VIS spectrophotometer. The FTIR data showed prominent peak in 3401.33, 2922.30, 2364.79, 2116.07, 1643.17, 1375.53, 1424.69 and 1324.03 cm-1 ranges. The SEM analysis showed that the AgNPs were spherical and slightly elongated in nature. The XRD peaks revealed the crystalline nature of the silver nanoparticles and the size of the synthesized nanoparticles was found to be in the range of 10-15 nm. The biologically synthesized silver nanoparticles were treated against the mosquito larvae of Culex quinquefasciatus and Aedes aegypti. The LC50 value of synthesized nanoparticle was identified as 1.23 and 1.19 mg L-1 for Culex quinquefasciatus and Aedes aegypti larvae. Further, LC90 values are also identified as 2.97 and 4.93 mg L-1, for Culex quinquefasciatus and Aedes aegypti respectively. Hence the present work suggests that the nanoparticles from Streptomyces sp. GRD would be appropriate for developing a biological control method of mosquito larval population.
  S. Sreedaran , K. Shanmuga Bharathi , A. Kalilur Rahiman , K. Rajesh , G. Nirmala and V. Narayanan
  New N-substituted cyclam ligands 1,8-[bis(3-formyl-2-hydroxy-5-methyl)benzyl]-1,4,8,11-tetraazacyclotetradecane, 1,8-[bis(3-formyl-2-hydroxy-5-methyl)benzyl]-4,11-dimethyl-1,4,8,11-tetraazacyclotetradecane, 1,8-[bis(3-formyl-2-hydroxy-5-bromo)benzyl]-1,4,8,11-tetraazacyclotetradecane, and 1,8-[bis(3-formyl-2-hydroxy-5-bromo)benzyl]-4,11-dimethyl-1,4,8,11-tetraazacyclotetradecane (L1-L4) were synthesized and mononuclear copper(II) and nickel(II) complexes prepared. The ligands and complexes were characterized by elemental analysis, electronic, IR, 1H NMR and 13C NMR spectral studies. N-alkylation causes red shifts in the λmax values of the complexes. Copper(II) complexes show one-electron, quasi-reversible reduction waves in the range -1.04 to -1.00 V. The nickel(II) complexes show one-electron, quasi-reversible reduction waves in the range -1.18 to -1.30 V and one-electron, quasi-reversible oxidation waves in the range +1.20 to +1.40 V. The reduction potential of the copper(II) and nickel(II) complexes of the ligands L1 to L2 and L3 to L4 shift anodically on N-alkylation. The ESR spectra of the mononuclear copper(II) complexes show four lines, characteristic of square-planar geometry with nuclear hyperfine spin 3/2. All copper(II) complexes show a normal room temperature magnetic moment value μeff = 1.70-1.74 BM which is close to the spin only value of 1.73 BM. Kinetic studies on the oxidation of pyrocatechol to o-quinone using the copper(II) complexes as catalysts and on the hydrolysis of 4-nitrophenylphosphate using the copper(II) and nickel(II) complexes as catalyst were carried out. The tetra-N-substituted complexes have higher rate constants than the corresponding disubstituted complexes.
  K. Shanmuga Bharathi , S. Sreedaran , R. Anitha Ayswarya , A. Kalilur Rahiman , K. Rajesh and V. Narayanan
  A new unsymmetrical end-off, aminomethylated N-methylpiperazine and aminomethylated diethanolamine armed binucleating ligand, 2-[bis(2-hydroxyethyl)aminomethyl]-6-[(4-methylpiperazin-1-yl)methyl]-4-formylphenol (HL), was synthesized by following sequential aromatic Mannich reactions. Mononuclear and binuclear Cu(II), Ni(II) and Zn(II) complexes were synthesized and characterized by elemental and spectral analysis. The EPR spectrum of the mononuclear copper complex shows four hyperfine splittings and the binuclear complex shows a broad signal due to anti-ferromagnetic interaction. The room temperature magnetic moment of the mono and binuclear copper complexes are 1.72 and 2.68 BM, respectively. Variable temperature magnetic moment study of the binuclear copper(II) complex shows weak antiferromagnetic coupling (-2J value, 21 cm-1). The mononuclear Ni(II) complex is square planar and diamagnetic. The six-coordinate binuclear Ni(II) complex shows a magnetic moment of 3.06 BM. Electrochemical studies of the complexes reveal that all mononuclear complexes show a single irreversible one-electron reduction wave and the binuclear complexes show two irreversible one-electron reduction waves in the cathodic region. Catecholase activity of copper(II) complexes using pyrocatechol as a model substrate and the hydrolysis of 4-nitrophenylphosphate using copper(II), nickel(II) and zinc(II) complexes as catalysts showed that binuclear complexes have higher rate constants than corresponding mononuclear complexes.
  S. Jagannathan , S. Chaansha , K. Rajesh , T. Santhiya , C. Charles and K.N. Venkataramana
  Vero cells are utilized for production of rabies vaccine. This study deals with the optimize quantity media require for the rabies vaccine production in the smooth roller surface. The rabies virus (Pasteur vaccine strain) is infected to monolayer of the various experimented bottles. To analyze the optimal quantity of media for the production of rabies viral harvest during the process of Vero cell derived rabies vaccine. The trials are started from 200 to 400 mL (PTARV-1, PTARV-2, PTARV-3, PTARV-4 and PTARV-5). The samples are taken in an appropriate time intervals for analysis of In Process Quality Control (IPQC) tests. The collected viral harvests are further processed to rabies vaccine in a pilot level and in addition to scale up an industrial level. Based on the evaluation the PTARV-2 (250 mL) show highly encouraging results for the Vero cell derived rabies vaccine production.
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