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Articles by K. Panda
Total Records ( 2 ) for K. Panda
  P. Banerjee , K. Panda , P. Nandi and S.K. Banerjee
  Health damaging effects of carbonated soft drink are largely based on epidemiological observations. The present study aimed to examine the possible physiological and biochemical effects of such drink in animal. Through oxiblot assay, fluorescence activated cell sorting assay and other biochemical investigations; it has been shown that consumption of such drink makes oxidative damages. Extensive such damages at the level of proteins in vivo in the liver, kidney and blood of experimental animal, guinea pigs, which cannot synthesize vitamin C like humans have been observed. These effects are also associated with significant cellular damages. In vitro studies reviled that such drink contains oxidants those are capable of direct protein oxidation. These observations establish physiological and biochemical link between consumption of carbonated soft drink and its deleterious effects in vitamin C deficient animals.
  P. Banerjee and K. Panda
  Damages of liver, kidney and serum proteins with apoptosis of these tissues in guinea pigs fed on carbonated soft drink was reported earlier. The present study establish the fact that if antioxidant supplementation is made along with carbonated soft drink such damages could be prevented. Vitamin C is a potent antioxidant and guinea pigs cannot synthesise ascorbic acid like mice. Excess sugar in carbonated soft drink increases production of destructive free radicals in animal. Ascorbic acid was supplemented orally in a measured dose along with carbonated soft drink, also in a measured volume to guinea pigs during the experimental period. Though oxyblot assay, fluorescence activated cell sorting assay and other biochemical findings, this paper reports that oxidative damages of the tissues along with apoptosis under the condition of carbonated soft drink feeding to guinea pigs could be prevented with supplementation of ascorbic acid.
 
 
 
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