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Articles by K. Padmaja
Total Records ( 1 ) for K. Padmaja
  J. Sravani , K. Padmaja , P. Eswara Prasad and B. Punya Kumari
  Objective: The aim of the study was to estimate the intensity of oxidative damage and alterations in antioxidant enzyme activities in liver of bisphenol-A (BPA) treated chick embryos. Methodology: An experiment was conducted to study the effect of BPA on thiobarbituric acid reacting substances (TBARS), glutathione (GSH) and antioxidant enzymes during embryonic development in chicks. Group I served as control, groups II-IV were injected with BPA dissolved in distilled water in three concentrations as 100, 250 and 500 μM, respectively, separately to 11th and 14th day old chick embryos. The developed embryos were sacrificed after 24 and 48 h of BPA exposure to collect liver tissues for estimation of TBARS, GSH and antioxidant enzyme activities (superoxide dismutase, catalase, glutathione peroxidise and glutathione-S-transferase). Results: The results showed a significant dose dependent increase in TBARS, GSH, GPX, GST and SOD after 24 and 48 h in both 11th and 14th day treated embryos. Whereas, CAT activity was not altered much after 24 h, but a significant increase was noticed after 48 h in liver of 11th and 14th day BPA treated chick embryos. The results revealed that increased levels of TBARS after 24 h of BPA treatment and were decreased after 48 h due to increased levels of antioxidant enzyme activities. Conclusion: Finally, it was concluded that BPA has induced oxidative stress and it was reduced by antioxidant enzyme activities, which indicates protective mechanism against the induced oxidative stress. The BPA is more toxic at early stages of embryonic development.
 
 
 
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