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| Articles
by
K. Othmani-Mecif |
Total Records (
1 ) for
K. Othmani-Mecif |
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S. Ait-Benali
,
K. Othmani-Mecif
and
Y. Benazzoug
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The altered lipid metabolism in the placenta
that is due to high maternal blood cholesterol, causes the
mother and fetus deterioration. Thus, we investigated the
effect of cholesterol-methionine enriched diet on serum,
cardiac lipids and oxidative stress parameters of female
rabbits and their offsprings. We analyze the effects of
different diets administered to females 15 days before the
mating and during 2 pregnancies on cardiovascular
tissues and on their relative offsprings (first and second
pregnancies). Thus, 3 lots are composed, a control group
fed with Standard Diet (SD), one fed with cooking Oil
enriched Diet (OD) and one with 1% cholesterol-0,25%
Met enriched Diet (CD). Results show that CD causes
newborn body weight reduction, reducing survival rate. In
female plasma, total cholesterol, PL, HDL-C and LDL-C
increase with CD. In plasma CD newborn, glucose and
HDL-C decrease while PL and LDL-C rise. Pro-oxidant
factors, MDA, AOPP, NO and anti-oxidant factors, UA,
AOA, Vit C rise in CD female. Newborns subject to CD
present modifications of MDA, NO, UA, AOA, Vit C,
Catalase activity and Iron. In newborn cardiac tissue, OD
and CD rise cholesterol and TG. The PL vary with OD.
Analysis of cardiac lipids by TLC shows the involvement
of PL, specialy phosphatidyl choline, lysophosphatidyl
choline and sphingomyelin. In cardiac CD newborn we
found a decrease of conjugated dienes, CAT, MDA and
an increase of iron. Our study indicates the negative
effects of CD (Chol+Met) ingested by female rabbit on
serum, cardiovascular lipids and oxidative stress factors
of their offspring. |
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