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Articles by K. Mori
Total Records ( 4 ) for K. Mori
  T. Aramaki , S.E. Boggs , W.W. Craig , H. Fuke , F. Gahbauer , C.J. Hailey , J.E. Koglin , N. Madden , K. Mori , R.A. Ong and T. Yoshida
  The General AntiParticle Spectrometer (GAPS) is a novel approach for indirect dark matter searches that exploits cosmic antideuterons. GAPS complements existing and planned direct dark matter searches as well as other indirect techniques, probing a different and unique region of parameter space in a variety of proposed dark matter models. The GAPS method involves capturing antiparticles into a target material with the subsequent formation of an excited exotic atom. The exotic atom decays with the emission of atomic X-rays and pions from the nuclear annihilation, which uniquely identifies the captured antiparticle. This technique has been verified through the accelerator testing at KEK in 2004 and 2005. The prototype flight is scheduled from Hokkaido, Japan in 2011, preparatory for a long duration balloon flight from the Antarctic in 2014.
  Y. Wada , Y. Hamamoto , H. Ikeda , S. Honjo , Y. Kawasaki , K. Mori and H. Koshiyama
  Aims  It has been recognized that blood pressure shows a seasonal variation, but it remains unknown whether diabetic nephropathy shows a seasonal variation. In the present study, we investigated the change in urinary albumin/creatinine ratio in relation to the season in Japanese patients with Type 2 diabetes.

Methods  A total of 430 subjects (275 male, 155 female) with Type 2 diabetes and early nephropathy (defined by UACR 30-300 mg/g creatinine) were included. One year was divided into four seasons and each season was defined as winter (December-February), spring (March-May), summer (June-August), and fall (September-November), and systolic and diastolic blood pressure, serum creatinine levels, and the urinary albumin/creatinine ratio were examined. The estimated glomerular filtration rate was also calculated and evaluated.

Results  The mean age (± SE) was 64.8 ± 0.8 years. The mean systolic blood pressure was significantly higher in winter than in summer (136 ± 0.68 vs. 133 ± 0.68 mmHg, P < 0.001). The urinary albumin/creatinine ratio showed a significantly higher value in winter than in summer (72.8 ± 4.4 vs. 54.6 ± 3.4 mg/g creatinine, P < 0.001). The curve of seasonal variation of this ratio showed a similar change to that of systolic blood pressure. No significant seasonal variation was observed in estimated glomerular filtration rate and diastolic blood pressure.

Conclusions  Our results suggest that there is a hitherto unknown seasonal variation in the urinary albumin/creatinine ratio, and that it may be necessary to consider this seasonal change, especially when performing an intervention study of nephropathy.

  M Okubo , Y Nishimura , T Shibata , K Nakamatsu , S Kanamori , I Tachibana , R Koike , T Nishikawa and K. Mori
  Objective

The purpose of this retrospective study was to analyze the results of accelerated hyperfractionation for patients with modeletaly advanced (T2 and T3) laryngeal cancer.

Methods

Between 1998 and 2007, 9 supraglottic carcinomas (6 T2N0M0, 2 T2N2M0, 1 T3N0M0), 30 glottic carcinomas (25 T2N0M0, 5 T3N0M0), and 1 T2N0M0 subglottic carcinoma were treated with definitive radiotherapy using accelerated hyperfractionation without concurrent chemotherapy. The dose-fractionation for 35 patients was 72.8 Gy/56 fractions/5.6 weeks, and that for four patients treated between 1998 and 2001 was 72 Gy/60 fractions/6 weeks. One patient who had been treated with steroid therapy for systemic lupus erythematosus was treated by 67.8 Gy/44 fractions/4.4 weeks.

Results

The local control and overall survival probabilities at 5 years for supraglottic carcinomas were 75% and 86%, respectively. Those for glottic carcinomas were 80% and 92%, respectively. The 5-year local control probabilities for T2 and T3 tumors were 85% and 56%, respectively. This excellent local control rate especially for T2 laryngeal carcinomas may be attributable to the effect of accelerated hyperfractionation. No late toxicities of grade 2 or more was noted among the 39 patients treated with 72.8 Gy/56 fractions or 72 Gy/60 fractions.

Conclusion

Accelerated hyperfractionation of 72.8 Gy/56 fractions/5.6 weeks using 1.3 Gy/fraction seems a safe and effective dose-fractionation for patients with moderately advanced laryngeal carcinomas.

  K. Mori
 

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) under ER stress conditions activates a series of homoeostatic responses collectively termed the unfolded protein response (UPR). The UPR is unique in which the molecular mechanisms it uses to transmit signals from the ER lumen to the nucleus are completely different to those used for signalling from the plasma membrane. An ER stress signal is sensed and transmitted across the membrane by a transmembrane protein(s) in the ER. Interestingly, the number of such functional sensors/transducers, ubiquitously expressed, has increased with evolution, for example, one in Saccharomyces cerevisiae, two in Caenorhabditis elegans and Drosophila melanogaster, and three in mammals. Accordingly, mammalian cells are able to cope with ER stress in a more sophisticated manner. Here, I summarize the mechanisms and activation consequences of UPR signalling pathways in yeast, worm, fly and mammalian cells. I also discuss how they have evolved to counteract ER stress effectively.

 
 
 
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