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Articles by K. Mallikarjuna
Total Records ( 3 ) for K. Mallikarjuna
  G. Narasimhulu , T. Lavanya , S. Rajeswara Reddy , K. Mallikarjuna , P. Visweswara Rao , Aishah Adam and K. Sathyavelu Reddy
  Recent studies are emphasizing on cure and or prevent the diabetes-associated complications by using herbal medicines, since complications are increasing around the world. The present study was aimed to investigate the pharmacological efficacies of Pimpinella tirupatiensis (Pt) extracts against diabetes-associated altered urea cycle and liver function markers. In this study, diabetes was induced by streptozotocin (STZ) injection (40 mg kg-1 b.wt.) in rats, and treated with P. tirupatiensis extracts for 30 days (750 mg kg-1 b.wt. orally). The significant (p<0.01) decrease in body weights, elevated serum glucose, urea, uric acid and creatinine levels along with elevated Aspartate amino transferase (AST) and Alanine amino transferase (ALT) activities were observed in diabetic rats. Interestingly, diabetic rats treated with P. tirupatiensis aqueous extracts showed significantly (p<0.01) lowered serum glucose levels and regained body weights compared to untreated diabetic rats. Elevated urea and uric acid contents were also significantly (p<0.01) controlled by P. tirupatiensis, which were similar to the standard anti-diabetic drug glibenclamide treatment. Furthermore, increased both AST and ALT activities were attenuated by P. tirupatiensis, which indicates diabetes-induced adverse effects on liver function markers were alleviated. These results clearly demonstrating that increased hostile milieu in urea cycle and liver function markers under diabetic condition could be reversed by P. tirupatiensis treatment. This study suggests that P. tirupatiensis aqueous extracts may be used as anti-diabetic remedy, however further confirmatory studies are necessary.
  T. Madhavi , B. Mahitha , K. Mallikarjuna and N. John Sushma
  In the present study the pro-oxidant activity of aluminum (Al) and the protective role of Bacopa monniera extract (BME) were determined in the medulla oblongata of albino rats. Albino rats were divided into four groups. First group of rats was used as control, second group of rats received oral dose of Aluminum maltolate only, third group of animals received Bacopa monniera extract (BME) and fourth group of animals received concurrently Aluminum maltolate (Al-M) plus Bacopa monniera (BME) extract respectively, for 4 weeks. At the end of the treatment, the medulla oblongata was removed and processed to examine the thiobarbituric acid reactive substances (TBA-RS) and antioxidant enzymes such as Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione Peroxidase (GPx). Oxidative stress was promoted in medulla oblongata following Aluminum administration. In contrast, BME extract exerted an antioxidant action which was related with an increase in the levels of antioxidant enzymes. Moreover, evidences from light microscopic images clearly demonstrating that Al-M-induced neuronal changes, which were minimized by BME treatment, architecture of medulla oblongata in Al-M+BME treated group was almost similar to the control.
  K. Mallikarjuna , G.R. Dillip , G. Narasimha , N. John Sushma and B. Deva Prasad Raju
  Nanotechnology can be defined as a research for the design, synthesis and manipulation of structure of particles with dimension smaller than 100 nm. Nanotechnology emerges from the physical, chemical, biological and engineering sciences where novel techniques are being developed to probe and manipulate single atoms and molecules. The biomimetic approaches of silver nanoparticles were reduced by a simple and eco-friendly process. The advantage of using plants for the synthesis of nanoparticles is that they are easily available, safe to handle and possess a broad variability of metabolites that may aid in reduction. We report a biomolecules hosting, rapid, environmentally benign, bio-degradable, non-toxic and green synthesis of silver nanoparticles by using Piper betle leaf broth as a reducing and stabilizing agent. The sizes of synthesized silver nanoparticles were formed on the treatment of aqueous AgNO3 solution with Piper betle broth, in the range of 3-37 nm. A UV visible spectrum of the aqueous medium containing silver ions demonstrated a peak at 440 nm corresponding to the surface plasmon resonance of silver nanoparticles; An XRD analysis reveals the crystalline nature of silver nanoparticles. The FTIR spectrum suggests that the proteins act as capping agents around the nanoparticles. The size and shape of the nanoparticles were employed by the Transmission Electron Microscope (TEM).
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