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Articles by K. Hattori
Total Records ( 4 ) for K. Hattori
  A.M. Anwar , K. Hattori , H. Ogata , M. Ashraf and Mandula
  The current research addresses Engineered Cementitious Composites (ECC) as a new alternative for retrofitting damaged concrete beams. Twenty-one plain concrete beams with pre-defined artificial cracks were prepared and repaired using different combinations of ECC alone or together with Carbon Fiber Reinforced Polymers (CFRP). The study showed that replacement of the inferior layer from the bottom of the deteriorated beams with a thin layer of ECC could be able to restore the beam to a condition better than its original state. Moreover, the repair with ECC was found effective in enhancing the member ductility as well. It was also shown that pasting CFRP directly over ECC substrate resulted in shear failure rather than the undesirable interfacial debonding mode of failure that typically occurs in case of concrete substrates.
  Ahmedou Ould Cherif Ahmed , R. Nagasawa , K. Hattori , D. Chongo and M.F. Perveen
  The study area is located in the Adrar region of Northern Mauritania covering the main watersheds of Atar district (Wadi Seguelli) and Aoujeft district (Wadi Labiodh). The agricultural activities of palm trees and gardening under palm trees are the main economical activities in this region. The farmers depend directly on the water points at the Wadis alluviums for irrigation and water supply. Meanwhile, this sensitive resources are under the influences of sever natural conditions and increasing demand for agricultural use as well as for domestic use. All these have made the development of water resources one of the difficult challenges in this region. This study aims at identifying suitable sites for Water Harvesting (WH) in the arid zone of Northern Mauritania (oasis area) using Landsat imagery and GIS technology. The combinations of different thematic layers; prepared from remote sensing images and ancillary data, such as land cover, geology, slope, drainage, geomorphology and lineament, using weighted overlay technique permit an effective way for monitoring and planning natural resources. The suitability analysis results reflect the limitations of suitable areas, which are concentrated at the Wadis beds along the valley zone with 1.4% of excellent to high suitability.
  M. Ashraf , A. Goyal , A.M. Anwar , K. Hattori , H. Ogata and S. Guo
  An evaluation was made on the mutual beneficial role of fly ash and ground granulated blast furnace slag in combating adiabatic temperature rise. The experimental program was designed in two stages; the main experiment consisted of two massive concrete specimens with dimensions (50x50x50) cm. In first stage of experiment, an adiabatic rise in temperature of specimens was measured. In second stage, the mechanical properties of massive concrete specimens were measured at the ages of 8, 14, 28, 56 and 91 days. At the age of 91 days, surface core and central cores were extracted from the surface and the central part of massive concrete specimens to determine compressive strength and dynamic modulus of elasticity. In the massive concrete specimen without any additive, the peak temperature noted was 64.5°C at 7th h after casting. While in mineral substituted concrete the maximum adiabatic temperature was 49.6°C at 19th h after casting. Lower rate of temperature rise in mineral substituted concrete has resulted in higher value of ultrasonic pulse velocity and ultimate compressive strength of concrete.
  T Igawa , H Tsunoda , T Tachibana , A Maeda , F Mimoto , C Moriyama , M Nanami , Y Sekimori , Y Nabuchi , Y Aso and K. Hattori
 

Fc engineering to increase the binding affinity of IgG antibodies to FcRn has been reported to reduce the elimination of IgG antibodies. Herein, we present a novel non-FcRn-dependent approach to reduce the elimination of IgG antibodies. Pharmacokinetic studies conducted in normal mice of various humanized IgG4 antibodies, which had identical constant regions but different variable region sequences, revealed that an antibody with a lower isoelectric point (pI) has a longer half-life. These antibodies exhibited comparable binding affinity to FcRn, and with the antibodies with lower pIs, a longer half-life was also observed in β2-microglobulin knockout mice, suggesting that differences in the pharmacokinetics were due to a non-FcRn-dependent mechanism. On the basis of our findings, we attempted to engineer the pharmacokinetic properties of a humanized anti-IL6 receptor IgG1 antibody. Selected substitutions in the variable region, without substitution in the Fc region, lowered the pI but did not reduce the biological activity and showed a significant reduction in the clearance of the antibody in cynomolgus monkey. These results suggest that lowering the pI by engineering the variable region could reduce the elimination of IgG antibodies and could provide an alternative to Fc engineering of IgG antibodies.

 
 
 
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