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Articles by K. Eklu-Gadegkeku
Total Records ( 3 ) for K. Eklu-Gadegkeku
  A. Diallo , K. Eklu-Gadegkeku , T. Mobio , S. Moukha , A. Agbonon , K. Aklikokou , E.E. Creppy and M. Gbeassor
  The present study had evaluated the protective effect of hydroalcoholic (50-50: v/v) and aqueous extracts of L. kerstingii and M. oleifera against lipid peroxidation induced in vivo and in vitro by either cadmium or ethanol. In a first series of experiments, lipid peroxidation induced in vitro by cadmium (5 μg mL-1) is decreased by hydroalcoholic extracts of M. oleifera and L. kerstingii (100 μg mL-1) by 94% and 50% (p<0.001) respectively whereas their aqueous extracts (100 μg mL-1) reduced the cadmium induced lipid peroxidation by 94% (p<0.001) and 44% (p<0.001) respectively. In vivo, the pretreatment with hydroalcoholic extracts of M. oleifera and L. kerstingii at 1 g kg-1 b.wt. reduced significantly ethanol-induced lipid peroxidation, in liver, by 53 and 50% (p<0.001), respectively. Similar results were found in the kidney even though lipid peroxidation is slightly increased by ethanol in this organ.
  A. Diallo , K. Eklu-Gadegkeku , A. Agbonon , K. Aklikokou , E.E. Creppy and M. Gbeassor
  In this study we investigated the acute and subchronic toxicity of hydroalcoholic (50-50: v/v) extract of Lannea kerstingii Engl. and K. Krause (Anacardiaceae) stem bark in Wistar rats. In the acute test, the dose of 5.000 mg kg-1 was used for the test limit. Animals were then observed individually 1 h post dosing and at least once daily for 14 days. The subchronic toxicity was evaluated through biochemical, haematological, body and relative organ weight of rats using daily oral doses of 500 and 1000 mg kg-1 b.wt., during 28 days. The limit dose of 5.000 mg kg-1 did not cause mortality or any sign of acute toxicity in any of the rats tested in the observatory period. In the subchronic test, L. kerstingii at 1000 mg kg-1 decreased significantly (p<0.05) the increment of body weight of rats from the 2nd to the 4th week. The decrease of the increment was 11, 11 and 10% on the 2nd, 3rd and 4th week, respectively. The relative weight of the spleen in the group treated with 1000 mg kg-1 b.wt. (0.19±0.01) showed a significant increase (p<0.05) as compared to control group (0.15±0.01). Biochemical and haematological parameters measured were similar between the control and treated groups.
  B. Bakoma , K. Eklu-Gadegkeku , A. Agbonon , K. Aklikokou , E. Bassene and M. Gbeassor
  The root of B. ferruginea is traditionnally used as a treatment for type 2 diabetes. The present study was investigated to evaluate the preventive effect of B. ferruginea on some markers of metabolic syndrome in type 2 diabetes (hyperlipidemia, glucose intolerance, obesity and oxidative stress) induced by high fructose and fat diet in male Wistar rat. The rats received fructose diet (10 mL kg-1 per day) during 42 days; at the 15th day to the 42nd day 15 min before, they received distilled water for high fructose diet group, metformine 100 mg kg-1 per day or extract 125 and 250 mg kg-1 per day for treatment group. The control group received only distilled water during the experiment. After 6 weeks of experiment, fasting blood glucose, liver MDA level, body weight gain, intra abdominal grease, serum triglyceride (TG) and total cholesterol levels in treated groups were significant lower than that of high- fructose diet group. However, rats in treated group were not found to have a significant change of blood HDL Cholesterol level. In the oral glucose tolerance test, rats in treated group had a significantly reduced blood glucose concentration during 180 min after glucose load, indicating that B. ferruginea root improved glucose tolerance. In conclusion, our plant can prevent metabolic syndrome induced by high fructose diet.
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