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Articles by K. Anandarajagopal
Total Records ( 4 ) for K. Anandarajagopal
  J. Anbu Jeba Sunilson , R. Suraj , G. Rejitha , K. Anandarajagopal , A.V. Anita Gnana Kumari and P. Promwichit
  In the present study, antimicrobial activity of various extracts of Zingiber officinale, Curcuma longa and Alpinia galanga were screened against the common food borne bacteria such as Escherichia coli, Salmonella enteriditis, Clostridium perfringens, Staphylococcus aureus, Campylobacter jejuni, Bacillus cereus and fungi such as Saccharomyces cerevisiae, Hansenula anomala, Mucor mucedo, Candida albicans using disc diffusion method. All the extracts showed significant antibacterial and antifungal properties. The methanol extracts (100 μg mL-1) revealed maximum zone of inhibition (p<0.001). Zingiber officinale and Curcuma longa possessed considerably greater activity than Alpinia galanga. These findings established the potential of the selected rhizomes of Zingiberaceae family as effective natural food preservatives.
  J. Anbu Jeba Sunilson , A.V. Anita Gnana Kumari , Abdullah Khan and K. Anandarajagopal
  Background and Objective: Medicinal plants have a vital role in the development of novel antimicrobial agents. The fruit Malus domestica is known as apple and commonly used to prevent tooth decay by killing dental pathogens. However, there were no scientific reports about the fruits of Malus domestica having antimicrobial activity against dental pathogens. The aim of this study was to extract the active constituents present in the fruits of Malus domestica by cold maceration method using petroleum ether, ethanol and water. Methodology: The antibacterial activity was assessed by cup plate method against five isolated dental pathogens such as Staphylococcus aureus, Streptococcus mutans, Lactobacillus subtilis, Klebsiella sp. and Pseudomonas sp. and the radial zone of inhibition was measured. Results: The results revealed that the ethanol extract (100 mg mL–1) has more potent antibacterial activity against S. aureus, S. mutans and Pseudomonas sp., followed by aqueous extract (100 mg mL–1) whereas, petroleum ether extract (100 mg mL–1) has not shown any zone of inhibition against the tested microorganisms. All the results were compared with standard drug chlorhexidine 0.2% w/v. Conclusion: Hence, the study concludes that Malus domestica fruit extracts possess significant (p<0.001, p<0.01, p<0.05) antibacterial activity against dental pathogens. The phyto chemical tests on ethanol extract showed the presence of bioactive constituents such as terpenoids, flavonoids, phenolic compounds and tannins which could be responsible for the antibacterial activity of M. domestica fruit.
  J. Anbu Jeba Sunilson , R. Suraj , K. Anandarajagopal , G. Rejitha , M. Vignesh and P. Promwichit
  In this study, petroleum ether, chloroform and methanol extracts of Codium decorticatum showed the presence of amino acids, carbohydrates, saponins, phytosterols, alkaloids and glycosides. The antibacterial activity against Gram-positive bacteria, such as Streptococcus pneumoniae, Staphylococcus aureus and Gram-negative bacteria, Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, Pseudomonas aeruginosa was carried out using cup-plate method. All the extracts showed good zone of inhibition against S. pneumoniae and K. pneumoniae at the concentrations of 25, 50 and 100 mg mL-1 compared with standard drugs, gentamicin and ampicillin (30 μg mL-1). To standardize the algae, elemental analysis was also carried out on C. decorticatum powder which revealed the presence of various elements. The present findings show the importance of C. decorticatum in producing new compounds having antibacterial activity.
  J. Anbu Jeba Sunilson , G. Rejitha , K. Anandarajagopal , Amitava Das , M. Muthappan and P. Promwichit
  Leaves of Cayratia carnosa have been ethnomedically claimed to possess a wide array of biological activities including anticancer activity. To verify the folklore claim, this study was performed in a Human breast carcinoma cell lines, MCF-7 and MDA-MB-231. Methanol and aqueous extracts of the leaves of C. carnosa showed cytotoxic effect on MCF-7 and MDA-MB-231 cell line, as determined with 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) microculture tetrazolium viability assay. Subcellular alterations were evaluated by using normal inverted microscope. Cells treated with methanol extract showed degeneration of cytoplasmic organelles, profound shrinkage of cells and apoptotic characteristics. The results showed that the methanol extract possesses cytotoxic effect which was greater than aqueous extract when compared to that of the control.
 
 
 
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