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Articles by K. Aklikokou
Total Records ( 7 ) for K. Aklikokou
  A. Teteh , , K. Aklikokou , M. Gbeassor , J. Buyse and E. Decuypere
  Effects of feed nutritive values on broiler performance are widely investigated. But, relationship between feed macronutrients’ levels and layer-type chicks (male and female) retains little attention. However, as for all developmental stages, starter diet composition may affect layer-type chick juvenile growth as well as physiological parameters. A total of 684 Hisex Brown layer-type chicks were studied. Chicks were divided, at random, into 3 groups with equal number of males and females: control, Low-Protein Diet (LP) and High Metabolisable Energy Diet (HME). During rearing period, feed intakes were recorded and chicks were weighed individually at the end of each week. Also, sample of chicks were used to weigh liver, at hatch and at 7, 14 and 56 day-old and to collect blood for glucose, total protein and triglyceride levels determination. Results indicate that layer-type chick growth rate, liver weight and feed efficiency were in following order HME > control > LP. With regard to chick sex, male chicks of HME and control diets grew better than female chicks from d 7 onward. But, in LP group, the weights of male and female chicks were comparable up to 49 d-old. At 7 d post-hatch, serum total protein and triglyceride levels of control chicks were higher than those of chicks of LP group while the levels of HME group were comparable to those of the two other groups. For total protein levels this trend lasted until 56 d of age. It can be concluded that low protein level of starter diet affects negatively feed efficiency and layer-type chick juvenile growth while high level of metabolisable energy improve feed efficiency and growth rate.
  Lawson-Evi Povi , A.E. Motto , K. Atchou , K. Tona , K. Eklu-Gadegbeku and K. Aklikokou
  Background and Objective: Pterocarpus erinaceus (Fabaceae), Amaranthus spinosus (Amaranthaceae) and Anogeissus leiocarpus (Combretaceae) are plants used in the treatment of diabetes many times. The present study was undertaken to observe the insulinomimetic activity of a different type of plants. Materials and Methods: The hypoglycemic effect of hydroalcoholic extracts from the stem bark of P. erinaceus and the roots of A. spinosus and A. leiocarpus was evaluated in ovo on 11 days-old chicken embryos and ex vivo on skeletal muscles isolated from rats. Results: All extracts reduced significantly the chicken embryos basal glycemia in the treated groups compared to the control group at the doses of 0.03 and 0.06 mg/100 μL. The extract of A. leiocarpus (0.5 and 1 mg mL1) increased (p<0.001 and p<0.0001) the absorption of glucose by the muscle in the presence and absence of insulin more than the extracts of Pterocarpus erinaceus and Amaranthus spinosus. Conclusion: Hence, it was concluded that, the three extracts decreased the basal glycemia in ovo. Whereas the extract of A. leiocarpus has an effect, similar to an insulinomimetic effect.
  A. Diallo , K. Eklu-Gadegkeku , T. Mobio , S. Moukha , A. Agbonon , K. Aklikokou , E.E. Creppy and M. Gbeassor
  The present study had evaluated the protective effect of hydroalcoholic (50-50: v/v) and aqueous extracts of L. kerstingii and M. oleifera against lipid peroxidation induced in vivo and in vitro by either cadmium or ethanol. In a first series of experiments, lipid peroxidation induced in vitro by cadmium (5 μg mL-1) is decreased by hydroalcoholic extracts of M. oleifera and L. kerstingii (100 μg mL-1) by 94% and 50% (p<0.001) respectively whereas their aqueous extracts (100 μg mL-1) reduced the cadmium induced lipid peroxidation by 94% (p<0.001) and 44% (p<0.001) respectively. In vivo, the pretreatment with hydroalcoholic extracts of M. oleifera and L. kerstingii at 1 g kg-1 b.wt. reduced significantly ethanol-induced lipid peroxidation, in liver, by 53 and 50% (p<0.001), respectively. Similar results were found in the kidney even though lipid peroxidation is slightly increased by ethanol in this organ.
  A. Diallo , K. Eklu-Gadegkeku , A. Agbonon , K. Aklikokou , E.E. Creppy and M. Gbeassor
  In this study we investigated the acute and subchronic toxicity of hydroalcoholic (50-50: v/v) extract of Lannea kerstingii Engl. and K. Krause (Anacardiaceae) stem bark in Wistar rats. In the acute test, the dose of 5.000 mg kg-1 was used for the test limit. Animals were then observed individually 1 h post dosing and at least once daily for 14 days. The subchronic toxicity was evaluated through biochemical, haematological, body and relative organ weight of rats using daily oral doses of 500 and 1000 mg kg-1 b.wt., during 28 days. The limit dose of 5.000 mg kg-1 did not cause mortality or any sign of acute toxicity in any of the rats tested in the observatory period. In the subchronic test, L. kerstingii at 1000 mg kg-1 decreased significantly (p<0.05) the increment of body weight of rats from the 2nd to the 4th week. The decrease of the increment was 11, 11 and 10% on the 2nd, 3rd and 4th week, respectively. The relative weight of the spleen in the group treated with 1000 mg kg-1 b.wt. (0.19±0.01) showed a significant increase (p<0.05) as compared to control group (0.15±0.01). Biochemical and haematological parameters measured were similar between the control and treated groups.
  B. Bakoma , K. Eklu-Gadegkeku , A. Agbonon , K. Aklikokou , E. Bassene and M. Gbeassor
  The root of B. ferruginea is traditionnally used as a treatment for type 2 diabetes. The present study was investigated to evaluate the preventive effect of B. ferruginea on some markers of metabolic syndrome in type 2 diabetes (hyperlipidemia, glucose intolerance, obesity and oxidative stress) induced by high fructose and fat diet in male Wistar rat. The rats received fructose diet (10 mL kg-1 per day) during 42 days; at the 15th day to the 42nd day 15 min before, they received distilled water for high fructose diet group, metformine 100 mg kg-1 per day or extract 125 and 250 mg kg-1 per day for treatment group. The control group received only distilled water during the experiment. After 6 weeks of experiment, fasting blood glucose, liver MDA level, body weight gain, intra abdominal grease, serum triglyceride (TG) and total cholesterol levels in treated groups were significant lower than that of high- fructose diet group. However, rats in treated group were not found to have a significant change of blood HDL Cholesterol level. In the oral glucose tolerance test, rats in treated group had a significantly reduced blood glucose concentration during 180 min after glucose load, indicating that B. ferruginea root improved glucose tolerance. In conclusion, our plant can prevent metabolic syndrome induced by high fructose diet.
  A. Missebukpo , K. Metowogo , A. Agbonon , K. Eklu-Gadegbeku , K. Aklikokou and M. Gbeassor
  Ixora coccinea L. (Rubiaceae) possess anti-inflammatory and antitussive properties. It is traditionally used for various respiratory ailments including catarrhal bronchitis cough and asthma. In the present study we investigated anti-asthmatic properties of an hydroalcoholic leaf extract of I. coccinea in an ovalbumin (OVA)-induced asthmatic rat model. We also evaluated the anti-allergic property of the extract by Abdominal Wall (AW) method and histamine-induced cutaneous reaction. Rats were sensitized with intraperitoneal (i.p.) ovalbumin and challenged by OVA intranasally to induce chronic airway inflammation. Randomized treatment groups of sensitized rats received I. coccinea extract or distilled water. I. coccinea extract at doses of 1000 and 1500 mg kg-1 suppressed eosinophilia and significantly inhibited AHR in rat with OVA-induced asthma. Based on lung histopathological study using hematoxylin and eosin I. coccinea reduced inflammatory cell infiltration and repaired epithelial cells damaged. In addition the extract at the same doses significantly decreased the diameter of the blue spot (16 and 55%, respectively) compared with the controls and inhibited the skin reactions induced by histamine (23.55 and 53.36%, respectively). In conclusion our results provide evidence that I. coccinea has anti-asthmatic properties and then can support its use in folk medicine to treat asthma.
  K.M. Joppa , K. Métowogo , A. Missebukpo , S. Agbèrè , A. Vovor and K. Aklikokou
  Background and Objective: Chronic anemia is the main cause of death of sickle cell patients. The way to manage their anemia is the stimulating of erythropoiesis by daily folate supplementation with its side effects. This study was aimed to evaluate in vitro antihemolytic and in vivo erythropoietic properties of Morinda lucida leaves hydroalcoholic extract (MLHE). Materials and Methods: The hemolysis was induced by a range of hypotonic solutions of NaCl in the absence and presence of 1.5 and 3 g L1 of MLHE. The toxicity of 28 days was also evaluated for MLHE at the doses of 250, 500 and 1000 mg kg1. Results: MLHE at 1.5 and 3 mg mL1 reduced, respectively 14.7% (p<0.01) and 23.2% (p<0.0001) this hemolysis. On other hand, three days after the anemia induction by phenylhydrazine administration, the reticulocyte rate had increased from 4.6% of red blood cells to 17.6% for the control versus 23.1% (p<0.02) in rats treated with 500 mg kg1 of MLHE. After 28 days of MLHE oral administration (250, 500 and 1000 mg kg1), hematology, nephrology and hepatic parameters showed no significant difference between the control groups and the treated rats. Only the platelets and white blood cells showed significant increasing but this is in the rat standard blood cell counts. Conclusion: The MLHE have anti-anemia properties by increasing the erythropoiesis and osmotic resistance of the red blood cells. Indeed, the results showed that it can admit that MLHE is not toxic.
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