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Articles by K. Sidik
Total Records ( 13 ) for K. Sidik
  Salmah, A.A. Mahmood and K. Sidik
  Wound healing activities of sweet basil was studies on cutaneous excision wounds in rats. Three groups of male Sprague Dawley rats each consist of 6 animals. Rats were placed individually in cages and all animals were experimentally wounded in the posterior neck area. Pure un-boiled honey was applied topically to wounds of Group 1 animals. Wounds of Group 2 rats were treated with honey in combination with O. basilicum L. alcoholic leave extract and solcoseryl - jelly was applied topically to wounds of Group 3 animals. The effects of vehicles on the rate of wound infections and on the rate of wound healing were assessed. Wounds of all groups of animals showed clean and remain sterile throughout the experiment. Wounds treated with honey in combination with plant extract and those treated with solcosery – jelly significantly (p<0.05) accelerates wound healing compared to wounds treated with honey alone. These results strongly document the beneficial effects of plant extract for the acceleration of wound healing process and the rates of wounds sterility.
  A.A. Mahmood , K. Sidik and I. Salmah
  The gastric protective effect of honey in combination with extract of fenugreek seeds was investigated in rats against ethanol-induced gastric damage. Macroscopically, oral administration of honey alone or honey in combination with seed extracts or with cimeidine induced a significantly decrease (p<0.05) in gastric lesions. Histological studies revealed that honey in combination with aqueous seeds extract was significantly more effective than honey alone or honey in combination with alcoholic extract in preventing gastric lesions formation. These observations showed that fenugreek aqueous seed extracts posse`s anti-ulcer potential.
  Mahmood, A.A. , K. Sidik and I. Salmah
  The aqueous extract of Carica papaya leaves were investigated for evaluation of wound healing potential in rats. Four groups of male Sprague Dawley rats each consist of 6 animals. All animals were experimentally wounded in the posterior neck area. Blank Vaseline was applied topically to wounds of Group 1 animals. Group 2 and Group 3 rats were treated topically with 5 and 10% Vaseline, respectively. Solcoseryl jelly was applied topically to wounds of Group 4 animals as a reference. The effects of vehicles on the rate of wound healing were assessed. Wounds treated with 5 and 10% Vaseline and wounds treated with solcoseryl jelly significantly accelerate wound healing potential compared to wounds treated with Blank Vaseline. These results strongly document the beneficial effects of plant extract for the acceleration of wound healing process in rats.
  Mahmood A.A. , K. Sidik , I. Salmah , K.A.R. Suzainur and K. Philip
  The aqueous extract of Ageratum conyzoides leaves was evaluation for their cytoprotective activity against ethanol-induced gastric lesions in rats. Four groups of male Sprague Dawley rats each consist of 6 animals. Group I animals were pretreated with phosphate buffer saline 5 mL kg 1 as a control, where as Group II and Group III rats were pretreated with 250 mg kg 1 and 500 mg kg 1 Ageratum conyzoides extract (5 mL kg 1), respectively. Group IV rats were pretreated with cimetidine 50 mg kg 1 as reference. After 30 min all animals were administered absolute ethanol 5 mL kg 1 orally and 15 min later all rats were sacrificed. Macroscopically, oral administration of absolute ethanol to rats pretreated with PBS significantly produced extensive hemorrhagic lesions of gastric mucosa, whereas animals pretreated with 250 mg kg 1 and 500 mg kg 1 aqueous extract or cimetidine significantly reduced the formation of gastric lesions compared to control group. Microscopically, pretreated rats with aqueous extract or cimetidine showed significantly marked inhibition of gastric lesions and marked reduction of submucosal edema compared to control group. These results strongly document the beneficial cytoprotective effects of plant extract against ethanol-induced gastric ulcer in rats.
  Mustafa, M.R. , A.A. Mahmood , K. Sidik and S.M. Noor
  The aqueous extract of Ageratum conyzoides leaves in combination with honey were investigated for evaluation of their wound healing potential in rats. Three groups of male Sprague Dawley rats each consist of 6 animals. Rats were placed individually in cages and all animals were experimentally wounded in the posterior neck area. Pure honey was applied topically to wounds of Group 1 animals. Wounds of Group 2 rats were treated with Ageratum conyzoides leaves extract in combination with honey (100 mg leaf extract/ml of honey w/v), and solcoseryl ointment was applied topically to wounds of Group 3 animals as a reference. The effects of vehicles on the rate of wound infection and on the rate of wound healing were assessed. Wounds of all groups of animals showed clean and remain sterile throughout the experiment. Wounds treated with plant extract in combination with honey, and wounds treated with solcosery ointment significantly (p<0.05) accelerate wound healing potential compared to wounds treated with honey alone. These results strongly document the beneficial effects of plant extract for the acceleration of wound healing process and the rates of wounds sterility.
  Philip, K. , A.A. Mahmood , B.Y. Hashim and K. Sidik
  Wound healing activities of plant extract mixtures in combination with honey was studied on cutaneous excision wounds in rats. Three groups of male Sprague Dawley rats were used and all animals were experimentally wounded in the posterior neck area. Pure un-boiled honey was applied topically to wounds of Group 1 animals. Wounds of Group 2 rats were treated with honey in combination with 5% plant extract mixtures, and honey in combination with 10% plant extract mixtures was applied topically to wounds of Group 3 animals. The effects of vehicles on the rate of wound healing were assessed. Wounds treated with honey in combination with 10% plant extract mixtures were significantly (p<0.05) accelerated wound healing compared to wounds treated by honey alone. These results strongly document the beneficial effects of 10% plant extract mixtures for the acceleration of wound healing process.
  K. Sidik , A.A. Mahmood and I. Salmah
  The aqueous extract of garlic (Allium sativum) in combination with honey was evaluated for wound healing activity in rats. Three groups of male Sprague dawley rats each consist of 6 animals. Rats were experimentally wounded in the posterior neck area. A thin layer of pure unboiled honey was applied topically to wounds of Group 1 animals. A. sativum L. in combination with honey was applied topically to wounds of Group 2 rats and a thin layer of solcoseryl - jelly was applied topically to wounds of Group 3 animals. The effects of these topical applicants on the rate of wound infections and on the rate of wound healing were assessed. Wounds of all animals showed clean and remain sterile throughout the experiment until complete healing. Wounds treated with garlic extract in combination with honey significantly accelerate wound healing compared to wounds treated with honey alone. In addition, wounds treated with solcoseryl-jelly also significantly accelerates wound healing compared to wounds treated with honey alone. These results strongly document the beneficial effects of garlic extract in combination with honey for the acceleration of wound healing process and the rates of wounds sterility.
  A.A. Mahmood , K. Sidik , I. Salmah and K.A.R. Suzainur
  Two groups of Sprague-Dawley adult male rats each consist of 8 animals were used throughout the experiment. All rats were subcutaneous inoculated once with 108cfu/ml of Pasteurella multocida strain PMB 202. In addition, Group 1 animals also received intra-muscular injection of dexamethasone (1.6 mg/animal/day) once daily for 9 days. Blood was collected from all animals before and after inoculation once daily for 9 days, for total and differential leucocytes count. Rats were scarified at day 9 for swabs culture and histological sections of liver, spleen and lung. In dexamethasone-treated animals (Group 1), total leucocytes count decreased after 24 hours (day 1) post-infection and then leucocytosis at day 4 (96 h), then leucopenia at day 8 and 9. Differential leucocytes count revealed gradual neutrophilia and lymphopenia at 120 h post infection (maximum), then neutropenia and lymphocytosis at day 7 and 9. Swab cultured from liver, spleen, and lung revealed positive for P. multocida and Staphylococcus aureus. Histological sections of such organs showed abscess formation surrounded by neutrophils. In Pasteurella multocida inoculated animals (Group 2), total leucocytes count started to increase gradually at day 1 and 2, then decreased to normal level at day 3 and leucocytosis at day 4 (maximum) and then gradual decreased to reach the normal level at day 9. Differential leucocytes count revealed, neutropenia and lymphocytosis at 24 hour post infection, and remain with the same level reaching maximun at day 9 with atypical lymphocytes. Swab cultured from liver, spleen and lungs showed negative for bacterial isolation. Histological sections of such organs reveled erythrocyte infiltration and mild infiltration of inflammatory cells.
  Mahmood, A.A , K. Sidik , U.R. Kuppusamy , K.A.R.Suzainur , M.Indran and I. Salmah
  Honey alone or, honey in combination with O. bacilicum oil or with cimitidine was found to posse`s significant anti-ulcer activity against ethanol-induced ulceration in experimental animal models macroscopically and microscopically. Significant inhibition was observed against ethanol-induced ulceration. Macroscopically, oral administration of absolute ethanol (5 ml kg-1 body weight) to fasted rats produced extensive hemorrhagic lesions of gastric mucosa. Pretreatment with honey alone (5 ml kg-1 body weight) or honey in combination with O. bacilicum oil extracts (5 ml kg-1 body weight) or honey in combination with cimitidine (5 ml kg-1 body weight) orally 30 minutes before administration of absolute alcohol significantly prevent or reduced the formation of such lesion. Microscopically, pretreatment rats showed significantly marked inhibition or reduction of gastric damage and no submucosal edema or leucocytes infiltration.
  Salmah , A.A. Mahmood , K. Sidik , M. H. M. Nazmul and K.A.R. Suzainur
  Eight plant species were picked randomly and their aqueous extracts have been screened to know their effects on the phagocytic capability and intracellular killing of E. coli bacteria by rat peritoneal macrophages. Macrophage cultures were incubated with different concentration of each plant extract for 1 hour. Among these aqueoud extracts, Ageratum conyzoides and Malastoma melabathricum inhibited the phagocytic capability and intracellular killing of E. coli compared with controls. Elicited (activated) cells have more phagocytic capability and intracellular killing than the resident (normal) macrophages. There were no differences in the viability of cells between treated cells with extract and controls.
  A.A. Mahmood , K. Sidik , I. Salmah , K.A.R. Suzainur and K.M. Yusoff
  The gastroprotective effects of honey and methanol extract of P. granatum L. fruit peel and N. sativa L seeds were investigated in the rat against ethanol-induced gastric damage. 5 groups of adult Sprague-Dawley rats were used throughout the experiment. Oral administration of absolute ethanol (5 ml kg-1 body weight) to fasted rats produced extensive lesions of gastric mucosa (Group 2). Pretreatment with honey (2.5 g kg-1 body weight) alone (Group 3) or honey in combination with each of P. granatum L. (0.1 g kg-1) (Group 4) or N. sativa L. (0.1 g kg-1) extracts (Group 5) orally 30 min before administration of absolute ethanol (5 ml kg-1) decreased or prevented the formation of such lesion. The observed protection was more pronounced when honey combined with each extract than honey alone. Honey in combination with N sativa L. completely ablated gastric lesions. Although the mechanism of gastric cytoprotection is unknown, honey in combination with each plant extracts appears to increase the resistance of gastric mucosal cells to the necrotizing effect of strong irritants (absolute alcohol). These results suggest that honey in combination with N. sativa L. or P. granatum L. extracts maintain the cellular integrity of the gastric mucosa, and might be beneficial in the treatment of a variety of diseases in which gastric mucosal injury is present.
  Salmah, A.A. Mahmood , K. Sidik , M.H.M. Nazmul , K.A.R. Suzainur and M. Indran
  The present work was done to investigate the possible effects of honey alone or in combination with each of Nicotiana tabacum L. leaves or Punica granatum L. fruit shells on the rate of wound healing process and on the rate of wound infection in rats. Three groups of adult male Sprague Dawley rats each group consist of six animals. All animals were experimentally wounded in the posterior neck area. Pure unboiled honey was applied topically to Group 1, whereas honey in combination with each of N. tabacum L. or P. granatum L. were used for dressing of group 2 and group 3, respectively. Wounds treated with honey in combination with each N. tabacum L. or P. granatum L. healed significantly (P<0.05) earlier than that treated with honey alone. All wounds showed clean and remain sterile until complete healing. These results strongly document the beneficial effects of honey in combination with each of N. tabacum L. or P. granatum L. for the acceleration of wound healing process, minimal scar formation and the rates of wounds sterility.
  A. A. Mahmood , K. Sidik , K. A. R. Suzainur , M. Indran and I. Salmah
  Four groups of adult male Sprague Dawley rats each consist of ten animals. All animals were experimentally wounded in the posterior neck area. Normal saline was applied topically to wounds of Group 1 as a negative control and pure un-boiled honey was applied topically to wounds of Group 2 animals. Wounds of Group 3 rats were treated with honey in combined with Chromolaena odorata aqueous leave extract. Group 4 rats act as positive control and treated with solcoseryl - Jelly. The effects of vehicles on the rate of wound healing and rate of infections were assessed. Wounds treated with honey alone or honey in combination with plant extracts and solcoseryl –Jelly showed clean and remain sterile and significantly healed earlier and much faster as compared to wounds treated with normal saline (Group 1). Wounds treated with solcosery – Jelly or honey in combination with plant extract also showed significantly earlier healing than honey alone There were no significant differences in wound healing rate between plant extract and solcoseryl - Jelly. This was indicated by improve rates of contraction and a decreased period of epithelialization and result in minimal scar formation. These results strongly document the beneficial effects of honey in combined with this extract for the acceleration of wound healing process, minimal scar formation, and the rates of wounds sterility.
 
 
 
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