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Articles by K. S Kim
Total Records ( 5 ) for K. S Kim
  H. J Lee , K. S Kim , J. S Jeong , M. A Cheong and J. C. Shim
  Background

The purpose of this study was to verify which muscle among the adductor pollicis (AP), orbicularis oculi (OO), and corrugator supercilii (CS) is a better predictor of optimal intubating conditions after administration of rocuronium.

Methods

In this prospective trial, 201 patients were randomized into six groups to receive rocuronium at a dose of 0.6 or 1.0 mg kg–1 during propofol–remifentanil–nitrous oxide anaesthesia. The tracheal intubation was performed after maximal neuromuscular block by acceleromyography at the thumb (AP), the eyelid (OO), and the superciliary arch (CS). The onset time, intubating conditions, peak vital signs, and bispectral index were assessed.

Results

The onset time of rocuronium in the OO and CS muscle was significantly shorter than in the AP muscle (P<0.001), but excellent intubating conditions were significantly increased in the AP (87%) and the CS (77%) compared with the OO (32%) after a dose of 0.6 mg kg–1 of rocuronium (P<0.05).

Conclusions

After administration of rocuronium, twitch monitoring at the OO allows a faster intubation but is associated with an unacceptable incidence of inadequate intubating conditions. Excellent intubating conditions are observed most frequently with AP monitoring but with the longest delay before intubation is attempted. Monitoring of the CS allows intubation earlier than that of AP with fewer patients having excellent but no patients having inadequate intubating conditions.

  Y. S Lee , K. S Kim and S. G. Chang
  No Description
  B. S Coates , D. V Sumerford , N. J Miller , K. S Kim , T. W Sappington , B. D Siegfried and L. C. Lewis
 

Microsatellite loci are standard genetic markers for population genetic analysis, whereas single nucleotide polymorphisms (SNPs) are more recent tools that require assessment of neutrality and appropriate use in population genetics. Twelve SNP markers were used to describe the genetic structure of Diabrotica virgifera virgifera (LeConte; Coleoptera: Chrysomelidae) in the United States of America and revealed a high mean observed heterozygosity (0.40 ± 0.059) and low global FST (0.029). Pairwise FST estimates ranged from 0.007 to 0.045, and all but 2 populations showed significant levels of genetic differentiation (P ≤ 0.008). Population parameters and conclusions based on SNP markers were analogous to that obtained by use of microsatellite markers from the identical population samples. SNP-based FST estimates were 3-fold higher than corresponding estimates from microsatellites, wherein lower microsatellite FST estimates likely resulted from an overestimate of migration rates between subpopulations due to convergence of allele size (homoplasy). No significant difference was observed in the proportion of SNP or microsatellite markers loci that were nonneutral within populations. SNP markers provided estimates of population genetic parameters consistent with those from microsatellite data, and their low back mutation rates may result in reduced propensity for error in estimation of population parameters.

  S. H Lee , K. S Kim , K. C Moon , Y Choi and H. I. Cheong
 

When compared to medullary nephrocalcinosis, cortical nephrocalcinosis is a rare and usually secondary to acute cortical necrosis or chronic glomerulonephritis. Here, we report two paediatric cases in which cortical nephrocalcinosis developed during the course of persistent nephrotic syndrome due to focal segmental glomerulosclerosis associated with an intronic mutation in the WT1 gene. The cause of development of cortical nephrocalcinosis was uncertain in both patients. This is the first case report of WT1 mutation-related glomerulopathy associated with cortical nephrocalcinosis, although it is currently unclear if the association is coincidental or causally related.

  S. H Lee , K. S Kim , N Fodil Cornu , S. M Vidal and C. A. Biron
 

Natural killer (NK) cells have the potential to deliver both direct antimicrobial effects and regulate adaptive immune responses, but NK cell yields have been reported to vary greatly during different viral infections. Activating receptors, including the Ly49H molecule recognizing mouse cytomegalovirus (MCMV), can stimulate NK cell expansion. To define Ly49H's role in supporting NK cell proliferation and maintenance under conditions of uncontrolled viral infection, experiments were performed in Ly49h–/–, perforin 1 (Prf1)–/–, and wild-type (wt) B6 mice. NK cell numbers were similar in uninfected mice, but relative to responses in MCMV-infected wt mice, NK cell yields declined in the absence of Ly49h and increased in the absence of Prf1, with high rates of proliferation and Ly49H expression on nearly all cells. The expansion was abolished in mice deficient for both Ly49h and Prf1 (Ly49h–/–Prf1–/–), and negative consequences for survival were revealed. The Ly49H-dependent protection mechanism delivered in the absence of Prf1 was a result of interleukin 10 production, by the sustained NK cells, to regulate the magnitude of CD8 T cell responses. Thus, the studies demonstrate a previously unappreciated critical role for activating receptors in keeping NK cells present during viral infection to regulate adaptive immune responses.

 
 
 
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