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Articles by K. Rafiq
Total Records ( 3 ) for K. Rafiq
  M.M. Haque , K. Rafiq , S.J. Sherajee , S. Ahmed , Q. Hasan and M. Mostofa
  The present investigation was carried out in 40 guinea pig with the aim to investigate the efficacy of some indigenous medicinal plants in the treatment of external wounds. Two wounds of 2.00 cm length and 0.5 cm depth were made on the opposite thigh muscles and the effects of some antibacterial and some indigenous medicinal plants leaves were observed separately. Among the antibacterial used in this studies comparatively Nebanol powder showed the best result and was more effective for the treatment of fresh wounds in which healing occurred with in 11 days, Where as it was taken 13 days for sulfanilamide powder and 15 days for dusting powder treated groups. In the present experiment the leaves of the Neem, Ganda, Mehedi and raw Halid were applied as fresh aqueous pastes for the treatment of artificially produce wound in guinea pig. In comparison to their effect, Neem leaves paste showed the more effectiveness where healing was completed on 15 days, Halud paste and Ganda leaves pastes showed the same results, where healing was completed on 17 days. The Mehedi paste was the least effective in which healing occurred on 19 days. This investigation suggested that Neem leaves fresh paste are more effective for wound healing in guinea pig which may be suggested for the treatment of fresh wound healing of other livestock.
  S.J. Sherajee , K. Rafiq , N.S. Juyena , S. Ahmed and M.A. Hashim
  To find out the effect of diazepam and promethazine hydrochloride on respiratory rate, pulse rate, temperature and production of clinical signs in goats and also to compare the effect of 2% lignocaine hydrochloride and 0.5% bupivacaine hydrochloride during paravertebral and epidural analgesia were investigated. A total of 16 apparently healthy Black Bengal goats with body weight of 8-12 (median 9.5 kg) kg were used and allocated in 8 groups. Both diazepam and promethazine, were used as sedatives. Diazepam and promethazine produced significant reduction (P<0.01) of respiratory rate and significantly (P<0.01) increase of the pulse rate, respectively. But both drugs produced reduction of temperature insignificantly. The important clinical signs recorded using diazepam was movement of legs, neck, salivation and sleepiness whereas with promethazine only a tranquilizing effect was recorded. With 2% lignocaine hydrochloride the onset of analgesia was rapid compared to 0.5 bupivacaine hydrochloride. But the duration was significantly longer in 0.5% bupivacaine than that of 2% lignocaine hydrochloride. Muscle relaxation was better with 2% lignocaine hydrochloride compared to 0.5% bupivacaine hydrochloride. This experiment suggested that both diazepam and promethazine are suitable as pre-medicants in goats and bupivacaine seemed to be better for longer duration of analgesia compared to lignocaine which may be used for shorter and minor surgery in goats.
  M.R. Amin , M. Mostofa , K. Rafiq , M.S. Hossain , M.M. Hasan and M.L. Sharmin
  The research work was carried out to investigate the effects of oral administration of glucocorticoids (dexamethasone and prednisolone), NSAIDs (aspirin and paracetamol) and sulfonylureas (gliclazide and glibenclamide) on body weight and blood glucose in mice. Out of seven groups of mice (each containing 5 mice), one group was kept as control without giving any drug. Another six groups of mice received separately dexamethasone (Oradexon®, 3.5 mg kg-1 b.wt.) prednisolone (Deltasone®, 8 mg kg-1 b.wt.), aspirin (Ecospirin®, 620 mg kg-1 b.wt.), paracetamol (Napa®, 333 mg kg-1 b.wt.), gliclazide (Comprid®, 64 mg kg-1 b.wt.) and glibenclamide (Glucotab®, 16 mg kg-1 b.wt) orally along with normal feed. A significant (p<0.05) reduction of body weight was recorded on 7th day following administration of dexamethasone, gliclazide and glibenclamide in mice. This reduction was highly significant (p<0.01) on 21st, 42nd and 70th day following dexamethasone, gliclazide and glibenclamide treated groups. Similarly prednisolone significantly (p<0.01) reduced body weight of mice in whole experimental period. A significant (p<0.01) increase of the blood glucose level was found due to dexamethasone, prednisolone, aspirin and paracetamol administration on 7th , 21st, 42nd and 70th day. On the other hand, a significant (p<0.01) decrease of blood glucose level was found in mice treated with gliclazide and glibenclamide in whole experimental period. It may be concluded that oral administration of glucocorticoids, NSAIDs and sulfonylureas have variable effects on blood glucose level in mice.
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