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Articles by K. R. Merikangas
Total Records ( 2 ) for K. R. Merikangas
  J Angst , L Cui , J Swendsen , S Rothen , A Cravchik , R. C Kessler and K. R. Merikangas
  Objective:

There is growing clinical and epidemiologic evidence that major mood disorders form a spectrum from major depressive disorder to pure mania. The authors examined the prevalence and clinical correlates of major depressive disorder with subthreshold bipolarity compared with pure major depressive disorder in the National Comorbidity Survey Replication (NCS-R).

Method:

The NCS-R is a nationally representative face-to-face household survey of the U.S. population conducted between February 2001, and April 2003. Lifetime history of mood disorders, symptoms, and clinical indicators of severity were collected using version 3.0 of the World Health Organization's Composite International Diagnostic Interview.

Results:

Nearly 40% of study participants with a history of major depressive disorder had a history of subthreshold hypo-mania. This subgroup had a younger age at onset, more episodes of depression, and higher rates of comorbidity than those without a history of hypomania and lower levels of clinical severity than those with bipolar II disorder.

Conclusions:

These findings demonstrate heterogeneity in major depressive disorder and support the validity of inclusion of subthreshold mania in the diagnostic classification. The broadening of criteria for bipolar disorder would have important implications for research and clinical practice.

  K. B Nelson , A. K Richardson , J He , T. M Lateef , S Khoromi and K. R. Merikangas
 

Objective  To examine the association of childhood headache disorders with markers of risk for cardiovascular and cerebrovascular disease.

Design  Information was collected on severe or recurrent headache or migraine in childhood or adolescence and on biomarkers predictive of vascular disease.

Setting  The National Health and Nutrition Survey, a nationally representative health survey.

Participants  Children or adolescents aged 4 to 19 years (n = 11 770) who took part in the National Health and Nutrition Survey in 1999 through 2004.

Main Exposure  Headache.

Main Outcome Measures  Body mass index; levels of C-reactive protein, homocysteine, serum and red blood cell folate, vitamin B12, methylmalonic acid, total cholesterol, high-density lipoprotein cholesterol, non–high-density lipoprotein cholesterol, triglycerides, and uric acid; and platelet count.

Results  Mean values for body mass index, C-reactive protein, and homocysteine were higher in children with than without headaches, and more children with headaches were in the highest quintile of risk for these factors. Serum and red blood cell folate levels were lower in children with headache. More children with headache were in the highest quintile of risk for 3 or more of these factors.

Conclusions  Several important risk factors for long-term vascular morbidity cluster in children and adolescents with severe or recurrent headache or migraine. Further study and screening of children with headaches may permit improved preventive management.

 
 
 
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