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Articles by K. Philip
Total Records ( 2 ) for K. Philip
  Mahmood A.A. , K. Sidik , I. Salmah , K.A.R. Suzainur and K. Philip
  The aqueous extract of Ageratum conyzoides leaves was evaluation for their cytoprotective activity against ethanol-induced gastric lesions in rats. Four groups of male Sprague Dawley rats each consist of 6 animals. Group I animals were pretreated with phosphate buffer saline 5 mL kg 1 as a control, where as Group II and Group III rats were pretreated with 250 mg kg 1 and 500 mg kg 1 Ageratum conyzoides extract (5 mL kg 1), respectively. Group IV rats were pretreated with cimetidine 50 mg kg 1 as reference. After 30 min all animals were administered absolute ethanol 5 mL kg 1 orally and 15 min later all rats were sacrificed. Macroscopically, oral administration of absolute ethanol to rats pretreated with PBS significantly produced extensive hemorrhagic lesions of gastric mucosa, whereas animals pretreated with 250 mg kg 1 and 500 mg kg 1 aqueous extract or cimetidine significantly reduced the formation of gastric lesions compared to control group. Microscopically, pretreated rats with aqueous extract or cimetidine showed significantly marked inhibition of gastric lesions and marked reduction of submucosal edema compared to control group. These results strongly document the beneficial cytoprotective effects of plant extract against ethanol-induced gastric ulcer in rats.
  Noor, S.M. , A.A. Mahmood , I. Salmah and K. Philip
  Cytoprotective effects are important in preventing the formation of gastric mucosa necrosis. Rafflesia hasseltii, used in traditional aboriginal Malay treatment of postpartum women, was evaluated for its cytoprotective effects. Both aqueous and ethanol extracts of the plant were evaluated to determine which extract offers better protection of the gastric mucosa in terms of inhibiting ulcer damage. Gastric ulcers were induced by oral administration of absolute ethanol (5mL kg-1) to 4 groups of fasting rats: the ulcer control rats which received no pre-treatments (Group 1); rats pre-treated with oral aqueous extracts of R. hasseltii (Group 2); rats pre-treated with oral ethanolic extracts of R. hasseltii (Group 3) and rats pre-treated with oral cimetidine (Group 4). Oral pre-treatments were given 30 minutes prior to oral induction of ulcers by absolute alcohol. Animals in Group 1 experienced severe gastric damage following absolute ethanol administration, with absolutely no inhibition. Group 2 and Group 3 rats exhibited the highest degree of inhibition to ethanol-induced ulcer damage, by a percentage 99.2 and 98.9% inhibition, respectively. Animals in Group 4, the cimetidine group, had only 59.4% inhibition to ethanol-induced gastric damage. The results suggested that R. hasseltii possess novel cytoprotective activity on gastric mucosal cells and undeniably beneficial for treating gastric ulcer.
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