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Articles by K. Hamasu
Total Records ( 2 ) for K. Hamasu
  K. Hamasu , K. Shigemi , Y. Tsuneyoshi , H. Sato , D.M. Denbow and M. Furuse
  The aim of the present study was to determine whether the sedative effects of L-proline are associated with the modulation of cholinergic neurotransmission. We investigated the effect of co-injection of L-proline with scopolamine, a Muscarinic Acetylcholine Receptor (M-AChR) antagonist, on behavior of neonatal chicks under isolation-induced stress. Intracerebroventricular (i.c.v.) injection of L-proline reduced spontaneous activity and the number of distress vocalizations, while co-injected scopolamine did not attenuate this effect implying that the M-AChR was not involved in the sedative effects induced by L-proline. In addition, the effect of L-proline on acetylcholineesterase activity in the telencephalon and diencephalon of chicks was investigated. No significant changes in acetylcholineesterase activity were observed in either the telencephalon or diencephalon. These results indicate that the sedative effects induced by L-proline are not mediated by the cholinergic system.
  T. Haraguchi , S. Tomonaga , I. Kurauchi , K. Hamasu , H. Sato , D.M. Denbow and M. Furuse
  Although, the central function of amino acids on food intake has been investigated, little information is available on the role of the amino acid L-proline. To clarify the central effect, several doses (0, 0.25, 0.5 and 1.0 mg) of L-proline were intracerebroventricularly (i.c.v.) injected into chicks under fasting (3 h) or ad libitum feeding conditions. Food intake was determined through 60 min post injection. Under fasting conditions, the following regression equation was obtained: food intake (g) = 3.047 + 3.496x 5.332 x2 (x in mg of L-proline, R2 = 0.466, RMS = 1.056). Similarly, the regression equation was obtained under ad libitum conditions as follows: food intake (g) = 0.479 (SE 0.164) + 2.130 (SE 0.815)x 2.452 (0.747)x2 (R2 = 0.313, RMS = 0.487). These results indicated that food intake was mildly stimulated by low levels of L-proline, but was suppressed by high levels in chicks. It is suggested that L-proline may act in the central nervous system to differentially regulate food intake, depending upon dose.
 
 
 
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