Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by K. H. Cho
Total Records ( 2 ) for K. H. Cho
  C. Y Dong , J Lim , Y Nam and K. H. Cho
 

Motivation: Synchronized bursting behavior is a remarkable phenomenon in neural dynamics. So, identification of the underlying functional structure is crucial to understand its regulatory mechanism at a system level. On the other hand, we noted that feedback loops (FBLs) are commonly used basic building blocks in engineering circuit design, especially for synchronization, and they have also been considered as important regulatory network motifs in systems biology. From these motivations, we have investigated the relationship between synchronized bursting behavior and feedback motifs in neural networks.

Results: Through extensive simulations of synthetic spike oscillation models, we found that a particular structure of FBLs, coupled direct and indirect positive feedback loops (PFLs), can induce robust synchronized bursting behaviors. To further investigate this, we have developed a novel FBL identification method based on sampled time-series data and applied it to synchronized spiking records measured from cultured neural networks of rat by using multi-electrode array. As a result, we have identified coupled direct and indirect PFLs.

Conclusion: We therefore conclude that coupled direct and indirect PFLs might be an important design principle that causes the synchronized bursting behavior in neuronal networks although an extrapolation of this result to in vivo brain dynamics still remains an unanswered question.

  C. H Seo , J. R Kim , M. S Kim and K. H. Cho
 

Motivation: Spatio-temporal regulation of gene expression is an indispensable characteristic in the development processes of all animals. ‘Master switches’, a central set of regulatory genes whose states (on/off or activated/deactivated) determine specific developmental fate or cell-fate specification, play a pivotal role for whole developmental processes. In this study on genome-wide integrative network analysis the underlying design principles of developmental gene regulatory networks are examined.

Results: We have found an intriguing design principle of developmental networks: hub nodes, genes with high connectivity, equipped with positive feedback loops are prone to function as master switches. This raises the important question of why the positive feedback loops are frequently found in these contexts. The master switches with positive feedback make the developmental signals more decisive and robust such that the overall developmental processes become more stable. This finding provides a new evolutionary insight: developmental networks might have been gradually evolved such that the master switches generate digital-like bistable signals by adopting neighboring positive feedback loops. We therefore propose that the combined presence of positive feedback loops and hub genes in regulatory networks can be used to predict plausible master switches.

 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility