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Articles by K Yamada
Total Records ( 3 ) for K Yamada
  T Torisu , K Yamada , T Fukui , M Yamaki , J Nakamura and I. Saito
 

Although there have been some reports on the relationship between craniofacial morphology and the activity of the temporal muscle attached to the coronoid process, such relationship is still unclear. The aim of the present study was therefore to investigate the relationship between the coronoid process and overall craniofacial morphology using lateral cephalograms of 60 female subjects (mean age 9.6 years) without mandibular deviation. Statistical testing was undertaken using stepwise regression analysis.

Anterior coronoid marginal depth correlated negatively (r = 0.71) with gonial angle, SNA, and overjet. The coronoid angle also correlated negatively (r = 0.86) with both the vertical and horizontal lengths from sella to the coronoid tip as well as with the horizontal length from sella to the posterior ramus margin. Furthermore, the coronoid length correlated positively (r = 0.61) with the coronoid angle and the anterior coronoid marginal depth. The coronoid width was also positively (r = 0.69) correlated with overbite.

Coronoid process morphology is related not only to mandibular morphology and position but also to maxillary position and the dental relationship in the anterior region. It therefore seems clear that coronoid process morphology might be related to temporal muscle functioning and its associated craniofacial morphological measurements.

  K Yamada , N Yamamoto , Y Yamada , T Mukohara , H Minami and T. Tamura
  Objective

ABI-007 is a novel Cremophor® EL-free nanoparticle albumin-bound paclitaxel. This Phase I study was designed to evaluate tolerability and determine recommended dose for Japanese patients when ABI-007 was administered in every-3-week schedule. Pharmacokinetics of paclitaxel was also assessed.

Methods

Patients with advanced solid tumors refractory to standard therapy received a 30 min intravenous infusion of ABI-007 every 3 weeks without pre-medications at 200, 260 or 300 mg/m2, respectively. Tolerability and recommended dose were determined by the standard ‘3 + 3’ rule.

Results

No dose-limiting toxicity was observed, despite the dose escalation. In another cohort, 260 mg/m2 was re-evaluated and resulted in no dose-limiting toxicity. Grade 3 or 4 neutropenia was reported for the majority of patients (n = 8) but no incidence of febrile neutropenia. Non-hematological toxicities were generally mild except for Grade 3 sensory neuropathy (n = 3). Pharmacokinetic study demonstrated the area under the curve of paclitaxel increased with increasing the dosage, and comparable pharmacokinetic parameters to the western population. Partial response was observed in three non-small cell lung cancer patients. Two of whom had received docetaxel-containing chemotherapy prior to the study.

Conclusions

ABI-007 administered in every-3-week schedule was well tolerated up to 300 mg/m2, and recommended dose was determined at 260 mg/m2 in consideration of efficacy, toxicities and similarity of pharmacokinetic profile in western studies. Additional studies of single-agent ABI-007 as well as platinum-based combinations, particularly in patients with non-small cell lung cancer, are warranted.

  H Tsujii , Y Eguchi , A Chenchik , T Mizutani , K Yamada and Y. Tsujimoto
 

We report the construction and application of a mammalian genome-wide RNAi library. The oligodeoxynucleotides encoding ~200,000 shRNA sequences that targeted 47,400 human transcripts were inserted into a lentivirus vector pFIV-H1-puro, and a pool of pseudovirus particles with a complexity of ~200,000 were used to infect target cells. From the cells surviving apoptogenic Fas stimulation, four candidate shRNA sequences were obtained that provided resistance to Fas-induced cell death, including two shRNAs for caspase-8, an shRNA for Bid, and an shRNA for Fas. The reconstructed shRNAs with these sequences were shown to reduce expression of the respective gene products and increase survival after Fas stimulation. When similar selection was performed for tunicamycin-induced apoptosis, no shRNA strongly inhibiting tunicamycin-induced cell death was isolated, although a few reconstructed shRNAs led to a slight increase of survival. Thus, this genome-wide shRNA library proved useful for selection of genes that are involved in cell death, but some limitation was also revealed.

 
 
 
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