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Articles by K Tamura
Total Records ( 5 ) for K Tamura
  S Iwasa , M Ando , M Ono , T Hirata , M Yunokawa , E Nakano , K Yonemori , T Kouno , C Shimizu , K Tamura , N Katsumata and Y. Fujiwara

This case report details a relapse with malignant transformation after the completion of bleomycin, etoposide and cisplatin chemotherapy for primary mediastinal seminoma, although the residual mass after chemotherapy was <3 cm in size and did not display an increased uptake of fluorodeoxyglucose when examined using positron emission tomography.

  C Shimizu , N Masuda , K Yoshimura , H Tsuda , M Mano , M Ando , K Tamura and Y. Fujiwara

Determinants of long-term outcome of patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer who received neoadjuvant chemotherapy (NAC) are not clear. The purpose of this study was to explore the prognostic factors of HER2-positive breast cancer patients administered NAC.


A retrospective analysis of 125 HER2-positive breast cancer patients treated by NAC using an anthracycline plus taxane with (HCN group, n = 54) or without trastuzumab (non-HCN group, n = 71) was performed. The clinical parameters, including the pathological complete remission (pCR) rate, disease-free survival (DFS) and organ-specific recurrence-free survival, were measured.


According to the results of the univariate analyses, age, clinical stage, pCR and axillary lymph node status were the factors significantly associated with the DFS. The inclusion of trastuzumab in the NAC regimen did not yield a significant difference in the DFS. Only the axillary lymph node status and age were found to be the significant factors affecting the DFS in a multivariate model. There were no significant differences in the patient/tumor characteristics between the HCN and non-HCN groups except for the pCR rate (50% in the HCN group vs. 24% in the non-HCN group) and the median follow-up time (738 days in the HCN group vs. 1579 days in the non-HCN group). Within the first 2 years from the initiation of NAC treatment, the central nervous system (CNS) was the most common site of first recurrence in the HCN group, whereas no cases of CNS metastasis were observed in the non-HCN group.


The pathological axillary node status and age were found to be the significant prognostic factors in HER2-positive breast cancer patients who received NAC. The pattern of recurrence may be different between HCN-treated and non-HCN-treated patients.

  T Kurata , N Yamamoto , T Komiya , J Tsurutani , M Miyazaki , K Tamura , K Takeda , K Nakagawa and M. Fukuoka

A combination Phase I study of gemcitabine and irinotecan in patients with previously untreated advanced non-small-cell lung cancer was conducted. Patients received gemcitabine and irinotecan on Days 1 and 8 every 3 weeks. A total of 11 patients were enrolled. Three of six patients who received the starting dose (gemcitabine, 800 mg/m2; irinotecan, 80 mg/m2) experienced dose-limiting toxicities (Grade 4 neutropenia, Grade 3 elevation of transaminase and Grade 5 interstitial pneumonia). At the reduced dose level (gemcitabine, 800 mg/m2; irinotecan, 60 mg/m2), all two assessable patients could not meet the administration criteria of Day 8 (one, Grade 2 elevation of transaminase; the other, Grade 1 diarrhea). No objective response was observed in eight evaluable patients. We could not determine the recommended dose of this combination because of intolerable toxicities and no efficacy. Therefore, it is difficult to forward this combination chemotherapy toward further studies.

  K Tamura , S Okayama and R. Shimizu

New multistage self-aligned quadrupole correction-lens systems are proposed for correcting the spherical aberration of a rotationally symmetrical lens in a probe-forming system such as electron beam lithography and focused ion beam. These multistage correction-lens systems consist of six- or eight-stage electrostatic quadrupole and aperture electrodes placed between the quadrupoles. An octupole field for the correction of aperture aberration is automatically created and aligned with a quadrupole field by supplying a voltage to the aperture electrode. The optical properties of the self-aligned quadrupole correction-lens systems are precisely simulated using the potential functions approximated from the calculated three-dimensional potential distributions. The lens components of the correction-lens systems are symmetric with respect to the mid-plane of the correction system, and the quadrupole excitations are anti-symmetric to the mid-plane. The simulated optical properties of the six- and eight-stage self-aligned quadrupole correction-lens systems are compared with a four-stage self-aligned quadrupole correction-lens system. Aperture aberration coefficients of the six- or eight-stage quadrupole system under non-excitation of the aperture electrodes become much smaller than those of the four-stage quadrupole system. It is found that the correction of spherical aberration using the six- or eight-stage self-aligned quadrupole correction-lens system can be easily achieved under the condition of considerably lower excitation of lens elements in comparison to the four-stage self-aligned quadrupole correction-lens system.

  S Isakozawa , K Kaji , K Tamura , X. F Zhang , A Sandborg and N. Baba

A new windowless X-ray energy-dispersive spectroscopy (XEDS) detector has been developed for an analytical electron microscope (AEM). Different from the conventional XEDS detectors, the new detector does not contain an ultra-thin window (UTW) and a vacuum gate valve which are the major causes of low X-ray detection sensitivity and vibration problems for AEM imaging, respectively. The performance of the newly designed detector was examined at an AEM column vacuum level of 105 Pa. The X-ray detectability was improved considerably; in particular, the sensitivity for detecting nitrogen characteristic X-ray signal was three times higher than that of the conventional UTW detectors.

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