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Articles by K Fujii
Total Records ( 3 ) for K Fujii
  H Fu , M Lin , Y Katsumura , A Yokoya , K Hata , Y Muroya , K Fujii and N. Shikazono

Silybin (SLB) and similar analogues, namely, hesperetin (HESP), naringenin (NAN) and naringin (NAR), are believed to be active constituents of natural flavonoids that have been reported as chemopreventive agents for certain cancers. Moreover, SLB and analogues have been determined to fast repair DNA bases from oxidative damage by pulse radiolysis techniques. The present study was designed to evaluate the protective effects of SLB and analogues on soft X-ray-induced damage to plasmid DNA in vitro. The DNA damage was determined by agarose gel electrophoresis. SLB and analogues were found to protect DNA from radiation damage at micromolar concentrations. Among the compounds tested, HESP and SLB were the most effective in preventing X-ray-induced formation of DNA single-strand breaks (SSB). A comparison of these results with other experiments showed that the ability of SLB and analogues to inhibit DNA damage in vitro correlated with the ability of the compounds to scavenge free radicals. Our work revealed that natural flavonoids, SLB and analogues may be used as potent radioprotectors against radiation damage.

  S Nakano , M Yoshida , K Fujii , K Yorozuya , Y Mouri , J Kousaka , T Fukutomi , J Kimura , T Ishiguchi , K Ohno , T Mizumoto and M. Harao

We recently developed a real-time virtual sonography (RVS) system that enables simultaneous display of both sonography and magnetic resonance imaging (MRI) cutaway images of the same site in real time. The aim of this study was to evaluate the role of RVS in the management of enhancing lesions visualized with MRI.


Between June 2006 and April 2007, 65 patients underwent MRI for staging of known breast cancer at our hospital. All patients were examined using mammography, sonography, MRI and RVS before surgical resection. Results were correlated with histopathologic findings. MRI was obtained on a 1.5 T imager, with the patient in the supine position using a flexible body surface coil. Detection rate was determined for index tumors and incidental enhancing lesions (IELs), with or without RVS.


Overall sensitivity for detecting index tumors was 85% (55/65) for mammography, 91% (59/65) for sonography, 97% (63/65) for MRI and 98% (64/65) for RVS. Notably, in one instance in which the cancer was not seen on MRI, RVS detected it with the supplementation of sonography. IELs were found in 26% (17/65) of the patients. Of 23 IELs that were detected by MRI, 30% (7/23) of IELs could be identified on repeated sonography alone, but 83% (19/23) of them were identified using the RVS system (P = 0.001). The RVS system was able to correctly project enhanced MRI information onto a body surface, as we checked sonography form images.


Our results suggest that the RVS system can identify enhancing breast lesions with excellent accuracy.

  C Yamauchi Kawaura , K Fujii , T Aoyama , M Yamauchi and S. Koyama

The purpose of this study was to clarify patient doses in the current otolaryngological multi-detector row computed tomography (MDCT) examinations. Patient doses were measured with an in-phantom dosimetry system which was composed of 48 photodiode dosemeters embedded within an anthropomorphic phantom. Organ and effective doses were evaluated according to the International Commission on Radiological Protection Publication 103. In neck CT, doses for salivary glands and for thyroid were high, 7.6–29.9 and 13.4–60.3 mGy, respectively. In sinus CT, brain and lens doses were high, 7.6–24.6 and 10.6–32.0 mGy, respectively, and in inner ear CT, lens dose was 8.0–35.3 mGy. Effective doses were 1.8–6.6 mSv in neck CT, 0.5–0.9 mSv in sinus CT and 0.3–0.6 mSv in inner ear CT. The present dose data would be used to estimate radiation risks for patients undergoing otolaryngological MDCT examinations.

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