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Articles by Jude E. Okokon
Total Records ( 5 ) for Jude E. Okokon
  Jude E. Okokon , Bassey S. Antia and Emem Umoh
  The ethanolic root extract of Hippocratea africana (200-600 mg kg-1) was evaluated for analgesic, anti-inflammatory and antipyretic properties. The extract dose dependently inhibited acetic acid-induced writhing, formalin-induced paw licking and thermally -induced pain in mice. The extract also inhibited fresh egg albumin, carrageenin and xylene-induced inflammation in mice. These inhibitions were statistically significant (p<0.05) when compared to control. The roots extracts was also found to reduce pyrexia in rats. The analgesic, anti-inflammatory and antipyretic activities of the extract may be related to its active constituents such as tannins, saponins, steroid and flavonoids.
  Jude E. Okokon , Lucky L. Nwidu and Grace A. Essiet
  The antiplasmodial activity of ethanol leaf extract of Aspilia africana was evaluated in mice infected with Plasmodium berghei berghei during early and established infections. Aspilia africana extract (100-300 mg kg-1 day-1) exhibited a significant (p<0.05) blood schizonticidal activity both in 4 day early infection and in established infection. The extract produced a significant (p<0.05) chemosuppression in both early and established infections tests though lower than that produced by chloroquine, 5 mg kg-1 day-1. Also, significant mean survival time was recorded in extract treated groups compared to the control group during established infection. The leaf extract posseses a promising antiplasmodial activity which can be exploited in malaria therapy.
  Jude E. Okokon , Bassey S. Antia , L.C. Osuji and Pius M. Udia
  Evaluation of antidiabetic and hypolipidaemic activities of ethanolic stembark extract of Mammea africana in rats was carried out. Treatment of streptozotocin diabetic rats with the extract caused a significant (p< 0.01) reduction in fasting Blood Glucose Levels (BGL) of the diabetic rats both in acute study and prolonged treatment (2 weeks). The activity of the extract was comparable to that of the reference drug, glibenclamide. M. africana treatment showed considerable lowering of serum total cholesterol, triglycerides, LDL cholesterol, VLDL cholesterol and an increase in HDL cholesterol in the treated diabetic group. This results suggest that the stembark extract of M. africana possesses antidiabetic and hypolipidaemic effect on streptozotocin induced diabetic rats.
  Jude E. Okokon and Bassey S. Antia
  The effect of ethanolic stembark extract of Mammea africana Sabine on total cholesterol, triglyceride and lipoproteins levels was studied on normal rats. The extract (30-90 mg kg-1) was orally administered to rats for 21 days after which they were sacrificed and blood taken for analysis. The extract produced a significant (p<0.05) dose-dependent decrease in the levels of total cholesterol, triglyceride, LDL-cholesterol and VLDL cholesterol, with a significant (p<0.05) increase in the level of HDL-cholesterol. The stembark extract has the potential to produce hypolipidaemia as well as preventing the development of atherosclerosis.
  Jude E. Okokon , Bassey S. Antia and Basil N. Ita
  Evaluation of antidiabetic activity of ethanolic root extract of Homalium letestui in rats was carried out. Antidiabetic potentials of the plant Homalium letestui extract (500-1000 mg kg-1) was investigated in streptozotocin induced diabetes in rats. Treatment of streptozotocin diabetic rats with the extract caused a significant (p<0.01) reduction in fasting Blood Glucose Levels (BGL) of the diabetic rats both in acute study and prolonged treatment (2 weeks). The activity of the extract was comparable to that of the reference drug, glibenclamide. This results suggest that the root extract of Homalium letestui possesses antidiabetic effect on streptozotocin induced diabetic rat.
 
 
 
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