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Articles by Juan Cantizani
Total Records ( 1 ) for Juan Cantizani
  Nuria De Pedro , Bastien Cautain , Juan Cantizani , Lorena Rodriguez , Francisca Vicente , RatnaTualsi and Sundar Rao Koyyalamudi
  Background: The mitochondrion is an essential organelles for producing most of the energy in the cell and also involved in a number of cellular activities in the cell. It plays an important role in the aging process. Mitochondrial dysfunctions are supposed to be responsible for many neurodegenerative diseases as Alzheimer’s Disease (AD), Parkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS). A growing body of evidence suggests that defects in mitochondrial metabolism and particularly of electron transport chain may play a role in neurodegenerative diseases. Secondary effects as proapoptotic factors and Reactive Oxygen Species (ROS) can be an early stage of several mitochondrial disorders. Objective: To evaluate the mitochondrial membrane potential, ROS generation, GSK-3β and CK-1δ activities of seven natural products (isoquercetin, rutin, avicularin, hesperetin, astragalin, luteolin and diosmin) by using well established assays in vitro assays. Materials and Methods: In this study, neuroprotective effect of seven natural products on rotenone-induced toxicity in a SH-SY5Y neuroblastoma cells model for PD. Results: In this study, seven natural products were assessed the mitochondrial membrane potential, ROS generation, GSK-3β and CK-1δ activities using well established assays. The most effective compound to prevent mitochondrial membrane depolarization and decrease the ROS levels was luteolin followed by isoquercetin and astragalin. Isoquercetin, astragalin, hesperetin and rutin have good activity against GSK-3β and no activity against CK-1δ. Conclusion: This study results suggest that isoquercetin and astragalin exerts its neuroprotective effect against rotenone due to its mitochondrial membrane potential, ROS generation, GSK-3β and CK-1δ activities.
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