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Articles by Joy Okpuzor
Total Records ( 3 ) for Joy Okpuzor
  Yahaya Tajudeen , Joy Okpuzor and Adedayo Titilola Fausat
  The general health problems that may arise from prolonged exposure to cement dust were investigated using black rats (Rattus rattus L.) living around a Portland Cement Company in Sagamu, Ogun State, Nigeria. 24 black rats, comprising of 12 rats from the cement factory and 12 rats from an environment free from cement dust were used for the study. Elemental analysis, hematology examination, histopathology examination and UV spectroscopy of the DNA of the rats in the two locations were carried out in the laboratory. The elemental analysis of the lung tissues of the exposed rats showed significant (p<0.05) concentrations of calcium, silicon, aluminum, chromium and lead compared to the control rats. The hematology examinations of the exposed rats showed marked reduction in the PCV, HB, RBC, WBC and total protein compared to the control rats. The histopathology analysis of the lung tissues of the exposed rats showed abnormal alveolar architecture, damaged bronchioles, disrupted bronchus, weak respiratory connective tissues, degenerated epithelium linings and inflammations. The liver tissues had abnormal cellular pattern, damaged central veins, disruption of portal triad and inflammations. And the kidney tissues showed damaged epithelium linings, convoluted tubules, damaged renal corpuscles and inflammations. There was no significant difference between the UV spectroscopy of the DNA of the exposed and the control rats. The results further confirm that cement dust is both toxic and pathogenic to animals including man. There is no doubt that people working or living within the vicinity of the cement company stand the risk of being affected by different types of diseases arising from exposure to cement dust.
  Adeola Oloyede , Joy Okpuzor , Olusesan Omidiji and Peter Odeigah
  Context: Joloo is a Nigerian herbal decoction used for managing breast tumor, ulcer, pain, fever and general malaise in southwestern Nigeria. Objective: The evaluation of the sub-chronic toxicity of Joloo, a Nigerian herbal decoction, is done by investigating its effects on biochemical, antioxidant, histopathologic and hematologic indices in normal albino rats. Materials and methods: Albino rats of either sex weighing between 128 and 160 g were divided into 4 groups of 10 rats each. Three test groups were orally administered 400, 800 and 1600 mg kg-1 body weight (b. wt.) doses of Joloo while control animals received distilled water over 28 days. Animal were weighed weekly and sacrificed after day 28. Organs were harvested, weighed and subjected to histopathologic assessment. Liver and blood samples were used for biochemical, antioxidant and hematological studies. Results: Mortality and signs of toxicity were absent in animals treated with 400 and 800 mg kg-1 doses of Joloo. At 1600 mg kg−1 dose, 20% mortality occurred. Decreased body weight and red blood cells (P < 0.05) observed at 1600 mg kg-1 differed significantly from control animals. No significant changes in body and organ weights presented. Significant increases in biochemical analytes and histopathologic parameters were unobserved. Rather, Joloo increased leukopoiesis and exhibited antioxidant activities at all doses. Discussion: Joloo proved safe at lower doses. The mortality at 1600 mg kg-1 could be due to disturbances in the physiology of the animals. The significant reduction in erythropoiesis could indicate early signs of toxicity. However, the unremarkable increases in hepatic and antioxidant enzymes may suggest that Joloo modulated oxidative status in the animals. Conclusion: Joloo seems safe at lower doses, but caution is advised at higher doses.
  Yahaya Tajudeen and Joy Okpuzor
  The variation in the degrees of exposure to elements in cement dust and health implications arising from working or living within the vicinity of a cement company was monitored using forty albino rats aged between four and five weeks old. The albino rats were exposed to cement dust for one hundred and eighty days at three selected different locations around the vicinity of a Portland cement company in Ewekoro, Ogun state, South-Western Nigeria. The results of the study revealed that the chemical elements associated with cement dust were detected in the lungs of the exposed rats and the amounts increased with closeness to the Cement Company and length of exposure. It was also observed that the exposed and un-exposed (Control) rats gained considerate weights during the period of the exposure and furthermore, there was a significant difference (p<0.05) between the mean weight of the rats placed at 250 m from the cement company and the control. There was a direct linear association between the mean weights of the rats and all the chemical elements after 180 days. Atomic absorption spectroscopy of the lung tissues of the exposed rats showed significant levels of calcium, silicon, aluminum, chromium and lead compared to the un-exposed rats (p<0.05). The histopathology study of the lung tissues of the exposed rats showed abnormal alveolar architecture, disrupted bronchus, damaged bronchioles, degenerated epithelium lining, weak respiratory connective tissues, inflammations and blue-black pigments. Some of the exposed rats died before the end of the exposure. The results of the investigation highlight the hazards of prolonged exposure to cement dust and underscore the need for urgent action for the protection of animals and plants.
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