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Articles by Joseph A. Anuka
Total Records ( 1 ) for Joseph A. Anuka
  Ben A. Chindo , Joseph A. Anuka and Karniyus S. Gamaniel
  Preparations of Ficus platyphylla Del. Holl. (Moraceae) have been used in the Nigerian traditional medicine for the management of epilepsy, psychosis, depression, pain and inflammation for many years and their efficacy is widely acclaimed among the Hausa communities of northern Nigeria. Here, we evaluated the acute and sub-acute toxicological properties of the methanol extract of F. platyphylla stem bark in rats, in order to determine its safety and to complement earlier efficacy studies on this widely used medicinal plant. Signs of toxicity, body weight changes, relative organs weight, feed and water consumption were monitored following 28 days of daily oral administration of graded doses of the extract in rats. Effects of the extract on haematological and biochemical parameters were also examined. The oral LD50 of the extract was estimated to be >5000 mg kg-1. The body weights of treated rats increased progressively, but the changes were not significantly different from the control groups. The extract neither produces significant changes in feed and water consumption nor affected the relative organs weight. Although, some insignificant variations were observed in haematological and biochemical indices, these important parameters were normal and within acceptable limits. No lesions or pathological changes of the organs attributable to treatment with the extract were observed from the pathological examinations. Present results provided evidence on that short-term administration of the methanol extract of F. platyphylla at doses lower than 1000 mg kg-1 is safe in rats and may not exert severe toxic effects.
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