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Articles by Jose G.M. Costa
Total Records ( 2 ) for Jose G.M. Costa
  Jose G.M. Costa , Samara A. Britoa , Eidla M.M. Nascimento , Marco A. Botelho , Fabiola F.G. Rodriguesa and Henrique D.M. Coutinho
  Pequi fruits have a high nutritional value, and they are rich in protein and vitamins. This work reports the results of the chemical characterization and antibacterial activity of “pequi” fruit pulp oil of Caryocar coriaceum (Wittm). Chemical composition was assessed by GLC and the antibacterial activity was assayed by the disk diffusion method. GLC indicated the following fatty acid content: oleic (55.79 g|100 g oil), palmitic (34.18 g|100 g oil), heptadecenoic (5.86 g|100 g oil), linoleic (1.80 g|100 g oil), stearic (1.73 g|100 g oil), eicosenoic (0.37 g|100 g oil), and palmitoleic (0.27 g|100 g oil). The oil showed antibacterial activity, inhibiting the growth of Salmonella cholerasuis (MIC < 1.25%), Staphylococcus aureus (MIC 1.25%), Pseudomonas aeruginosa (MIC 1.25%) and Streptococcus pneumoniae (MIC 5%). There is great interest in extending the use of this natural product so that derivatives with combined social, economic and therapeutic value can be produced.
  Karla K.A. Santos , Edinardo F.F. Matias , Celestina E. Sobral-Souza , Saulo R. Tintino , Maria F.B. Morais-Braga , Glaucia M.M. Guedes , Francisco A.V. Santos , Ana Carla A. Sousa , Miriam Rolon , Celeste Vega , Antonieta Rojas de Arias , Jose G.M. Costa , Irwin R.A. Menezes and Henrique D.M. Coutinho
  Context: Chagas disease, caused by Trypanosoma cruzi, is a public health problem. Currently, chemotherapy is the only available treatment for this disease, and the drugs used, nifurtimox and benzonidazol, present high toxicity levels. An alternative for replacing these drugs are natural extracts from Momordica charantia L. (Cucurbitaceae) used in traditional medicine because of their antimicrobial and biological activities. Objective: In this study, we evaluated the extract of M. charantia for its antiepimastigote, antifungal, and cytotoxic activities. Materials and methods: An ethanol extract of leaves from M. charantia was prepared. To research in vitro antiepimastigote activity, T. cruzi CL-B5 clone was used. Epimastigotes were inoculated at a concentration of 1 x 105 cells/mL in 200 μl tryptose-liver infusion. For the cytotoxicity assay, J774 macrophages were used. The antifungal activity was evaluated by microdilution using strains of Candida albicans, Candida tropicalis, and Candida krusei. Results: The effective concentration capable of killing 50% of parasites (IC50) was 46.06 μg/mL. The minimum inhibitory concentration (MIC) was ≤ 1024 μg/mL. Metronidazole showed a potentiation of its antifungal effect when combined with an extract of M. charantia. Conclusions: Our results indicate that M. charantia could be a source of plant-derived natural products with antiepimastigote and antifungal-modifying activity with moderate toxicity.
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