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Articles by Jong-Ho Lee
Total Records ( 2 ) for Jong-Ho Lee
  Joo Young Lee , Jin Young Kim , Vitaly Ryu , Bom-Taeck Kim , JaeHyung Koo , Jong-Ho Lee and Jeong Won Jahng
  This study was conducted to examine if γ-amino Butyric Acid (GABA)-ergic neurotransmission is implicated in the regulation of stress-induced feeding. Rats received GABAA receptor antagonist bicuculline before each stress session during 10 days of daily restraint stress. The hypothalamic mRNA expressions of corticotropin-releasing hormone and neuropeptide Y were analyzed by in situ hybridization and the plasma corticosterone with radioimmunoassay. Bicuculline ameliorated the decrease in food intake by repeated restraints but not by a single restraint. Corticosterone increase responding to acute stress but not to repeated restraints was attenuated by bicuculline. Stress-induced expression of corticotropin-releasing hormone was blunted by bicuculline pre-treatment. Restraint stress did not affect neuropeptide Y expression, regardless of bicuculline pre-treatment. It is concluded that GABAA receptors may mediate chronic but not acute, stress-induced suppression in food intake, possibly in relation with anorectic action of the hypothalamic corticotropin-releasing hormone and the hypothalamic neuropeptide Y may not be implicated in its regulatory mechanism.
  Vitaly Ryu , Sang Bae Yoo , Kyung-Nyun Kim , Jong-Ho Lee and Jeong Won Jahng
  This study was conducted to examine the tentative implications of nicotinic receptor activation and nitric oxide release in the acquisition and extinction of lithium-induced conditioned taste aversion learning. Rats were pretreated with nitric oxide synthase inhibitor Nω-nitro-L-arginine methyl ester or nicotinic acetylcholine receptor antagonist mecamylamine either at the conditioning (sucrose-lithium pairing) or at each drinking test. The Nω-nitro-L-arginine methyl ester prior to lithium chloride (unconditioned stimulus) did not affect the lithium-induced formation of conditioned taste aversion; however, Nω-nitro-L-arginine methyl ester at a dose of 30 mg kg–1 prior to each sucrose (conditioned stimulus) drinking test significantly suppressed sucrose intake. Mecamylamine prior to lithium did not affect the acquisition of lithium-induced conditioned taste aversion, but at high dose (2 mg kg–1) it facilitated the extinction. Mecamylamine (2 mg kg–1) prior to each sucrose test delayed the extinction of lithium-induced conditioned taste aversion memory. Results suggest that nitric oxide may be implicated in the extinction memory formation of lithium-induced conditioned taste aversion, possibly in relation with the activation of nicotinic acetylcholine receptor.
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