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Articles by John David Kabasa
Total Records ( 2 ) for John David Kabasa
  Rebecca Nalubega , John David Kabasa , Deo Olila and John Kateregga
  This study evaluated the antibacterial activity of aqueous extracts of eleven plants against gram positive (Staphylococcus aureus, Streptococcus faecalis) and gram negative (Escherichia coli and Salmonella typhimurium) bacteria using the agar well diffusion assay and tube dilution method. Qualitative tests were carried out to investigate the phytochemical composition for ether, ethanol and aqueous extracts of these plants. In general, gram-positive bacteria were more susceptible than gram-negative bacterial species. The aqueous extract of Moringa oleifera had activity on all the four bacteria species. The aqueous extracts of Persea americana had the lowest MIC (0.25 g mL-1) and therefore, the best activity on Salmonella typhimurium. Leonotis nepetifolia with MIC (0.25 g mL-1) and Lantana trifolia with MIC (0.15 g mL-1) had the lowest MICs and therefore, the best activity on Staphylococcus aureus. The most prominent phytochemicals of medicinal importance established in the extracts of most test plants were tannins, sterols, basic alkaloids and alkaloid salts. These results suggest that Moringa oleifera extracts could be of value in the discovery of compounds which may be effective in the treatment of a number of bacterial diseases. Similarly, Persea americana extracts may contain active compounds that could be used for treatment of salmonellosis while Leonotis nepetifolia and Lantana trifolia may contain compounds effective against staphylococcal infections. All the 11 tested plants contain phytochemicals with potentially beneficial therapeutic effects.
  Immaculate Nakalembe and John David Kabasa
  As a contribution to a search of alternative drugs against emerging resistant pathogenic strains, this study aimed at determination of anti-microbial activity and identification of the potential bioactive compounds in two medicinal mushrooms (Termitomyces sp. (Bunyanaka) and Termitomyces microcarpus) used for treating coughs, boils, sore throat or tonsillitis. To achieve this target, the fractions were obtained from petroleum ether and methanol crude extracts and tested in vitro for anti-microbial activities against selected bacterial strains and a fungus. The bioactive compounds were identified using GC-MS. Gram positive bacteria were more sensitive than gram negative ones. Isolated fractions had activity at a MIC value of 3.13-200 μg mL-1. Similarly, petroleum ether fractions had high activity than methanol ones. Interestingly, Pseudomonas aeruginosa was more sensitive to Termitomyces sp. fractions with a MIC value of 50-75 μg mL-1. Several bioactive compounds were identified in the mushrooms. Further studies should be done to elucidate these compounds as a contribution towards drug development.
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