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Articles by John Akighir
Total Records ( 2 ) for John Akighir
  Ojochenemi Ejeh Yakubu , Chinedu Imo , Christopher Shaibu , John Akighir and Daniel Simon Ameh
  Background and Objectives: Diabetes mellitus has been a great worry to humanity and the scientific community and researchers have made it a point of challenge and responsibility to bring an end to the quantum of havocs posed by this monster. This study was carried out to evaluate the effects of ethanolic leaf extract and stem-back extract of Adansonia digitata (AD) on liver function, haematology and blood glucose level in alloxan-induced diabetic Wistar rats. Materials and Methods: Twenty-five Wistar rats were distributed into 5 groups of 5 animals each. The test animals were administered alloxan (150 mg kg1) intraperitoneally and were monitored for 72 h for the development of hyperglycemia. Group 1 served as normal control, group 2 served as diabetic control, while groups 3and 4 were diabetic rats treated orally with ethanolic leaf and stem-bark extracts of Adansonia digitata (100 mg kg1), respectively for 21days. Group 5 animals were diabetic rats treated with anti-diabetic drug (glibenclamide). Results: The result of this study indicated a reduced blood glucose level and a significantly (p<0.05) reduced liver function parameters evaluated in the alloxan-induced diabetic treated rats compared with the diabetic control rats. However, there was no specific pattern of increase/decrease in the haematological parameters. Conclusion: This study showed that alloxan-induced diabetes mellitus caused a possible liver disease condition and alteration of the haematological indices. However, administration of the AD leaves extract and AD stem-bark extract exhibited the ability of treating the inflammation and alterations caused by alloxan-induced diabetes.
  Ojochenemi Ejeh Yakubu , Richard-Harris N. Boyi , Christopher Shaibu , Moses Adondua Abah and John Akighir
  Background and Objective: Plant-derived medicines have been used in the treatment and management of human diseases. This study was aimed to investigate the antioxidant properties of ethanolic extract of Hymenocardia acida stem bark as well as its phytochemical composition using GC-MS. Materials and Methods: The stem bark of H. acida was collected within the premises of Federal University Wukari, Taraba state, washed, air dried at room temperature for one week and analyzed for antioxidant properties and phytochemical composition. Results: The following ranges for the ascertained antioxidant parameters were observed: Total antioxidant capacity (34-72 mg mL1), Total phenolic content (115-242 mg mL1) and total flavonoid content (70-122 mg mL1). The following fatty acids, fatty acids methyl esters and volatile organic compounds were revealed by Gas Chromatography-Mass Spectrometry analysis of H. acida: 15-hydroxypentadecanoic acid, oleic acid, palmitoleic acid, 9-octadecenal (Z)-, Behenic alcohol, 1(3H)-iso benzofuranone, 6, 7-dimethoxy-3- [2-(2- methoxyphenyl)-2-oxoethyl, 2-(Acetoxymethyl)-3-(methoxycarbonyl) biphenylene, Heptasiloxane 1, 1, 3, 3, 5, 5, 7, 7, 9, 9, 11, 11, 13, 13-tetradecamethyl. Conclusion: This study showed that Hymenocardia acida stem bark has a broad spectrum of antioxidant activity and contains appreciable levels of bioactive compounds such as; Behenic alcohol and Oleic acid which have therapeutic applications.
 
 
 
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