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Articles by Jitendra Nath De
Total Records ( 2 ) for Jitendra Nath De
  Abhijit Dey and Jitendra Nath De
  Venomous snakebite has been a major cause of mortality and morbidity across the Asian, African and Latin American countries. Lack of medical infrastructure, ineffectiveness of conventional antivenin and malpractice by the local quacks worsen the scenario. The present review deals with the pharmacological investigations performed in different botanicals for antiophidian principles. It also includes a list of certain traditionally used medicinal plants with potential anti snake venom efficacy. The authors have compiled a number of plants active in vitro and/or in vivo against the toxicity of various snake venoms causing an array of biological symptoms. This review also compiles the information regarding the possible use of plant derived natural product based antivenins in order to find cheap and effective alternative source of snake venom antidote especially for the third world tropical countries. From a variety of literature sources the data has been collected mentioning the plants alphabetically and their respective families with notes on plant parts and solvent system used, in vitro and in vivo analyses, activity against the toxicity and biological symptoms related to poisonous snakebite, dose dependence, experimental models, efficacy of the isolated compound(s), ethnobotanical and clinical relevance etc.
  Abhijit Dey and Jitendra Nath De
  Background: Leprosy, an infectious disease, caused by bacteria Mycobacterium leprae and Mycobacterium lepromatosis has been known since biblical times. The disease is associated with damage of the skin, nerve, limbs and eyes. It has a long incubation period and children are more susceptible. Common forms of leprosy are tuberculoid and lepromatous and a few intermediates. It is not very contagious and tentative mode of transmission is respiratory droplets. The disease is widespread throughout the tropical, subtropical and temperate regions of the world but is prevalent among the underprivileged of the third world countries. Results: The present review deals with the literature covering the use of antileprotic plants, their pharmacological investigations and ethnobotanical remedy of the disease. The authors have tried to bridge between the folklore use of the herbs and their pharmacological investigations for antileprotic properties. Conclusions: Although different antileprotic drugs are available in the market, herbs and herbal constituents have been neglected as a possible remedy. Most of the present treatments are difficult, time consuming, expensive and with adverse side effects. Development of drug resistance in the bacteria is another major concern worldwide. Considering the facts, herbal remedy can be an exciting aspect in the treatment of the disease with less side effects and at a reasonable cost. The vast ethnic knowledge inherited by the local medical practitioners can be exploited scientifically to find out novel antileprotic compounds.
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