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Articles by Jinhua Wang
Total Records ( 2 ) for Jinhua Wang
  Libin Xu , Yaqi Liu , Xia Zhu , Jinhua Wang and Chao Wang
  The process for flocculation of lotus leaf beverage by using soyabean protein was investigated in this study. Processing factors were soybean heating temperature, NaOH concentration and soybean heating time. Genetic algorithm-artificial neural network model was used to optimize the different influencing factors on flocculation. Back-propagation network was chosen as the network model. Weights and basis of network was optimized using genetic algorithm. The developed GA-ANN which included 9 hidden neurons could predict clarifies degrees of lotus leaf beverage with correlation of 0.94. The results indicating that GA-ANN model provided an accurate prediction for lotus leaf clarify beverage degrees.
  Jinhua Wang , Chunjing Bian , Jing Li , Fergus J. Couch , Kangjian Wu and Robert Chunhua Zhao
  Expression of the BRCA2 tumor suppressor gene is tightly linked to its roles in DNA damage repair and maintenance of chromosomal stability and genomic integrity. Three transcription factors that activate (USF, NF-κB, and Elf1) and a single factor that represses (SLUG) BRCA2 promoter activity have been reported. In addition, a 67-bp region (–582 to–516) associated with inhibition of promoter activity has been identified. However, it remains unclear how the 67-bp region contributes to regulation of BRCA2 expression. Here, we describe the affinity purification of a 120-kDa protein that binds to a silencer-binding region within the 67-bp repression region of the BRCA2 promoter. Mass spectrometry revealed the identity of the protein as poly-(ADP-ribose) polymerase-1 (Parp-1). Gel shift, antibody super-shift, and chromatin immunoprecipitation (ChIP) assays demonstrated that Parp-1 is associated with the BRCA2 promoter both in vitro and in vivo. Furthermore, Parp-1 inhibitors (either 3-AB or NU1025) and Parp-1 gene specific siRNA resulted in increased levels of endogenous BRCA2 expression. Inhibition of Parp-1 activity (by 3-AB) reduced histone 3 lysine 9 acetylation and blocked Parp-1 binding to the BRCA2 promoter. These results indicate that Parp-1 down-regulates BRCA2 expression through an interaction with a repression region of the BRCA2 promoter.
 
 
 
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