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Articles by Jing Hu
Total Records ( 2 ) for Jing Hu
  Guiqing Peng , Yan Yan , Chengliang Zhu , Shiqun Wang , Xiaohong Yan , Lili Lu , Wei Li , Jing Hu , Wei Wei , Yongxin Mu , Yanni Chen , Yong Feng , Rui Gong , Kailang Wu , Fengmin Zhang , Xiaolian Zhang , Ying Zhu and Jianguo Wu
  Borna disease virus (BDV) is one of the infectious agents that causes diseases of the central nervous system in a wide range of vertebrate species and, perhaps, in humans. The phosphoprotein (P) of BDV, an essential cofactor of virus RNA-dependent RNA polymerase, is required for virus replication. In this study, we identified the gamma-aminobutyric acid receptor-associated protein (GABARAP) with functions in neurobiology as one of the viral P protein-interacting cellular factors by using an approach of phage display-based protein-protein interaction analysis. Direct binding between GABARAP and P protein was confirmed by coimmunoprecipitation, protein pull-down, and mammalian two-hybrid analyses. GABARAP originally was identified as a linker between the gamma-aminobutyric acid receptor (GABAR) and the microtubule to regulate receptor trafficking and plays important roles in the regulation of the inhibitory neural transmitter gamma-aminobutyric acid (GABA). We showed that GABARAP colocalizes with P protein in the cells infected with BDV or transfected with the P gene, which resulted in shifting the localization of GABARAP from the cytosol to the nucleus. We further demonstrated that P protein blocks the trafficking of GABAR, a principal GABA-gated ion channel that plays important roles in neural transmission, to the surface of cells infected with BDV or transfected with the P gene. We proposed that during BDV infection, P protein binds to GABARAP, shifts the distribution of GABARAP from the cytoplasm to the nucleus, and disrupts the trafficking of GABARs to the cell membranes, which may result in the inhibition of GABA-induced currents and in the enhancement of hyperactivity and anxiety.
  Yuelan Xuan , Jing Hu , Kailai Xu , Xiandeng Hou and Yi Lv
  When carbon disulfide (CS2) was passing through the surface of nanosized-CeO2 (nano-CeO2), strong chemiluminescence (CL) emission was observed. Based on this phenomenon, a novel sensitive gas sensor was demonstrated for the determination of CS2. The luminescence characteristics and optimal parameters, such as the morphology of the CeO2, wavelength, temperature and the flow rate of carrier gas, were investigated in detail. Under the optimal conditions, the CL intensity versus the concentration of CS2 was linear in the range of 0.9–12.6 μg mL–1, with a linear correlation coefficient (R) of 0.999 and a limit of detection (S/N = 3) of 3.7 ng mL–1 for CS2. The relative standard deviation (R.S.D.) for the determination of 3.6 μg mL–1 CS2 was 1.2% (n = 5). There is no or weak response to foreign substances, such as alcohol (methanol, ethanol, and n-butanol), aldehyde (formaldehyde and acetaldehyde), acetone, ethyl acetate, chloroform, carbon tetrachloride, toluene, chlorobenzene, hexane and hydrogen sulfide. The stability and durability of the sensor were examined by sampling 7.2 μg mL–1 CS2 vapor into the sensor everyday for 3 h over two weeks, with a long-term R.S.D. of less than 6.0%. Finally, the proposed sensor was applied to the determination of CS2 in artificial air samples.
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