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Articles by Jiedong Wang
Total Records ( 2 ) for Jiedong Wang
  Xiangbo Xu , Xihua Chen , Jiedong Wang and Bin He
  MMPs are vital in menstruation. This study aimed to investigate their expressions in a mouse menstrual-like model by pharmacologic progesterone withdrawal. The model was prepared by administration of mifepristone after decidualization of ovariectomized mice. Immunohistochemistry was performed to detect the locations of Matrix Metalloproteinase (MMPs) proteins. MMP3 was present in the focal subluminal stromal zone, epithelium, decidual zone and interface between the basal zone and functional zone from 0-24 h and epithelium and subluminal epithelium stroma from 32-48 h. MMP7 was present in the basal zone, epithelium and mid decidual zone from 0-24 h and a similar location to MMP3 from 32-48 h. MMP9 was present in the basal zone and focal zone of the subluminal stroma from 0-24 h, epithelium and the edge of tissue breakdown at 32 h, basal zone and the subluminal stroma at 40 h and the subluminal stroma at 48 h. MMP13 was present in the mid decidual zone at 24 and 32 h and epithelium at 40 and 48 h. MMP2 was present in the basal zone and mid decidual zone from 0-24 h, the mid decidual zone at 32 h and no staining at 40 and 48 h. The locations of MMPs protein in the model displayed regional character and showed consistency with those in the mice model by physiological progesterone withdrawal and in primates.
  Ning Wang , Linlin Geng , Shucheng Zhang and Jiedong Wang
  The aim of this study was to explore the temporal and spatial relationship among pinopodes, implantation sites and implantation window and to suggest a method to obtain a sufficient number of pinopodes for further study. The endometrium was divided into two groups: the natural pregnancy group and the pseudopregnancy group. The distribution and density of pinopodes in different phases were observed by scanning electron microscopy in order to determine the phase and location that pinopodes enriched on the surface of endometrium. In the natural pregnancy group, a small number of tiny and round pinopodes started to protrude on the endometrial surface from day 3.5 of pregnancy. On day 4.5, a large number of pinopodes protruded from the endometrial surface, concentrating in where the implantation sites were located. On day 5.5, pinopodes started to regress. Pinopodes reached their peak at the implantation sites on the phase of implant window. In comparison, in the pseudopregnancy group, pinopodes reached their largest scale and density on day 3 of pseudopregnancy and earlier than they were in the natural pregnancy group. Pinopodes concentrated in the crypts of anti mesometrial side. In the natural pregnancy group, the peak of pinopodes appeared temporal and spatial coincident with implantation sites and implantation window. In the pseudopregnancy group which was earlier than they were in the natural pregnancy group. Whether in the natural pregnancy group or in the pseudopregnancy group, researchers can obtain endometrium containing pinopodes without interference of other tissues containing none or scarce pinopodes. This makes it possible to better understand the biochemical characteristic of pinopodes by studying biological molecules in pinopodes. This also helps to further explain the mechanism of recognition in other words, the relationship between the maternal endometrium and embryo in the process of apposition and attachment during the early implantation.
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