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Articles by Jianhua Shi
Total Records ( 2 ) for Jianhua Shi
  Haitao Wang , Fenglong Zhang , Binglian Bai , Peng Zhang , Jianhua Shi , Dingyi Yu , Yunfeng Zhao , Yue Wang and Min Li
  A series of hexacatenar liquid crystals containing the 1,3,4-oxadiazole group as rigid core, i.e. 1,4-bis[(3,4,5-trialkoxyphenyl)-1,3,4-oxadiazolyl]- benzene (P-P-oxd-n), were designed and synthesised. Based on a detailed study of their thermotropic phase behaviour and mesophase structures, it was revealed that columnar phases are generated in these materials. Furthermore, combination of experimental and calculated results enabled a proposal for the molecular packing in the mesophase. The photoluminescent properties of these materials were examined using P-P-oxd-8 as an example. A strong blue light emission (λmax = 456 nm) was observed in P-P-oxd-8 and a higher quantum yield was obtained in dilute chloroform solution.
  Jianhua Shi , Tianyi Zhang , Chunlei Zhou , Muhammad Omar Chohan , Xiaosong Gu , Jerzy Wegiel , Jianhua Zhou , Yu-Wen Hwang , Khalid Iqbal , Inge Grundke-Iqbal , Cheng-Xin Gong and Fei Liu
  Two groups of tau, 3R- and 4R-tau, are generated by alternative splicing of tau exon 10. Normal adult human brain expresses equal levels of them. Disruption of the physiological balance is a common feature of several tauopathies. Very early in their life, individuals with Down syndrome (DS) develop Alzheimer-type tau pathology, the molecular basis for which is not fully understood. Here, we demonstrate that Dyrk1A, a kinase encoded by a gene in the DS critical region, phosphorylates alternative splicing factor (ASF) at Ser-227, Ser-234, and Ser-238, driving it into nuclear speckles and preventing it from facilitating tau exon 10 inclusion. The increased dosage of Dyrk1A in DS brain due to trisomy of chromosome 21 correlates to an increase in 3R-tau level, which on abnormal hyperphosphorylation and aggregation of tau results in neurofibrillary degeneration. Imbalance of 3R- and 4R-tau in DS brain by Dyrk1A-induced dysregulation of alternative splicing factor-mediated alternative splicing of tau exon 10 represents a novel mechanism of neurofibrillary degeneration and may help explain early onset tauopathy in individuals with DS.
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