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Articles by Jian Yu
Total Records ( 3 ) for Jian Yu
  Junhua Chen , Qi Liu , Jian Yu and Yajing Zheng
  The locomotive layout which is extremely hard to modify after the construction, has direct impact on the daily transport efficiency and economic benefit of the railway transportation company. Therefore, it should be optimized once the rail network pattern is changed. The regional heavy haul rail network is a half open transportation system. Constant changes exist in the long period. As a result, the modification of locomotive system productivity layout is hard to be timely and effective. This problem differs from the normal logistic location problem and has complex influencing factors. Existing literatures mainly focus on the qualitative solutions which cannot precisely show the advantages and disadvantages of the alternative solutions and lack enough persuasion. The two key points of this problem is (1) Reasonable and reliable index system and (2) Feasible and practical models and algorithms. The numerical example takes the regional heavy haul rail network of Shenhua Group. The evaluation index system that can reflect the random factors is built. Then the model and the corresponding algorithm that can comprehensively evaluate the alternative solutions are proposed, through the combination of the fuzzy analytical hierarchy process and gray correlation analysis method. The locomotive layout optimization results conform to the reality well and promote the locomotive operational efficiency which will have positive impact on the development of the long-locomotive-line operation mode.
  Sean P. Garrison , John R. Jeffers , Chunying Yang , Jonas A. Nilsson , Mark A. Hall , Jerold E. Rehg , Wen Yue , Jian Yu , Lin Zhang , Mihaela Onciu , Jeffery T. Sample , John L. Cleveland and Gerard P. Zambetti
  The p53 tumor suppressor pathway limits oncogenesis by inducing cell cycle arrest or apoptosis. A key p53 target gene is PUMA, which encodes a BH3-only proapoptotic protein. Here we demonstrate that Puma deletion in the Eµ-Myc mouse model of Burkitt lymphoma accelerates lymphomagenesis and that ~75% of Eµ-Myc lymphomas naturally select against Puma protein expression. Furthermore, approximately 40% of primary human Burkitt lymphomas fail to express detectable levels of PUMA and in some tumors this is associated with DNA methylation. Burkitt lymphoma cell lines phenocopy the primary tumors with respect to DNA methylation and diminished PUMA expression, which can be reactivated following inhibition of DNA methyltransferases. These findings establish that PUMA is silenced in human malignancies, and they suggest PUMA as a target for the development of novel chemotherapeutics.
  Wenjing Luo , Jinyi Liu , Jingxia Li , Dongyun Zhang , Mingchao Liu , James K. Addo , Shivaputra Patil , Lin Zhang , Jian Yu , John K. Buolamwini , Jingyuan Chen and Chuanshu Huang
  p53, one of the most commonly mutated genes in human cancers, is thought to be associated with cancer development. Hence, screening and identifying natural or synthetic compounds with anti-cancer activity via p53-independent pathway is one of the most challenging tasks for scientists in this field. Compound JKA97 (methoxy-1-styryl-9H-pyrid-[3,4-b]-indole) is a small molecule synthetic anti-cancer agent, with unknown mechanism(s). In this study we have demonstrated that the anti-cancer activity of JKA97 is associated with apoptotic induction via p53-independent mechanisms. We found that co-incubation of human colon cancer HCT116 cells with JKA97 inhibited HCT116 cell anchorage-independent growth in vitro and tumorigenicity in nude mice and also induced a cell apoptotic response, both in the cell culture model and in a tumorigenesis nude mouse model. Further studies showed that JKA97-induced apoptosis was dramatically impaired in Bax knock-out (Bax-/-) HCT116 cells, whereas the knock-out of p53 or PUMA did not show any inhibitory effects. The p53-independent apoptotic induction by JKA97 was confirmed in other colon cancer and hepatocarcinoma cell lines. In addition, our results showed an induction of Bax translocation and cytochrome c release from the mitochondria to the cytosol in HCT116 cells, demonstrating that the compound induces apoptosis through a Bax-initiated mitochondria-dependent pathway. These studies provide a molecular basis for the therapeutic application of JKA97 against human cancers with p53 mutations.
 
 
 
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