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Articles by Jian Wang
Total Records ( 13 ) for Jian Wang
  Jian Wang , Jianling Sun , xinyu Wang and Hang Chen
  Process allocation for load distribution can improve system performance by utilizing resources efficiently. For primary-backup based fault tolerant system, a classic load-balancing process allocation method (two-stage allocation algorithm) has been proposed that can balance the load before as well as after faults occurrence. But two-stage allocation algorithm has bad scalability since its load-balancing performance reduces dramatically when each primary process is duplicated more than once (i.e., has more than one backup process). In this study, we present an improved algorithm named RSA (R-Stage Allocation algorithm) that can have the load better balanced no matter how many backup processes each primary process owns; Simulations are also used to compare the proposed algorithm with the two-stage allocation algorithm and the experimental results show that when extending to replicated R-Resilient processes, RSA has significantly better load distribution performance than two-stage allocation algorithm.
  Jian Wang , Na Zhao , Wei Du , Yang Zhao , Ye Qian and Zuo Jiang
  In this study, we assume a software process model with independent functions as a component. The vaguer and ambiguity aspects of human thinking and reasoning process lead people to utilize fuzzy theories to solve certain problems. The goal of this paper is to employ the method of fuzzy mathematic to classify the components in component library during the process of software evolution. To classify component, the target parameters extracted from components are selected out before the standardization and the clustering is performed after the establishment of fuzzy equivalent matrix. This paper outlines the overall processes of the classification of a component and finally an example is discussed as a case study.
  Ying-He Qin , Wei Wang , Jia Yao , Jian Wang , Xiao-Mao Guo and Song-Jia Lai
  Meat flavor, one of the most important characteristic of meat quality in farm animals is significantly determined by the Inosine Monophosphate Acid (IMP) content. However, the genetic regulation underlying IMP synthesis has largely remained unknown at the present. In this study, researchers cloned the AMPD1 gene in rabbit and investigated the mRNA expression in longissimus dorsi muscle at 40, 70 and 90 days old, respectively using real-time PCR method. The association between mRNA expression and IMP content was subsequently studied among 48 individuals from two breeds of Tianfu black rabbit (n = 24) and Harbin albino rabbit (n = 24). Total 899 bp fragment containing entire coding region was obtained for rabbit AMPD1 gene. There is no significant difference of IMP content between the two breeds rabbits in the three studied ages (p>0.05). The slaughter age has significant effect on the IMP content with the highest value at 90 days old (3.41±0.29) and the lowest values at 40 days old (2.50±0.39). Researchers detected the negative correlation between IMP content and AMPD1 mRNA expression (r = -0.916, p<0.05). The AMPD1 gene have not significant effects on IMP contents. The results suggested the potential function of AMPD1 to determine the IMP content in rabbit which is significant to conduct the MAS for improving the meat quality.
  Wei Wang , Xiao-Mao Guo , Jian Wang and Song-Jia Lai
  Meat products normally contain low omega-3 fatty acids and high ratio of n-6/n-3 fatty acids may contribute to the prevalence of many diseases. In order to obtained in such beef with high levels of omega-3 fatty acids will be more healthy to meet people’s diet, researchers generated the fat-1 transgenic simmental crossbred cattle expressing the Caenorhabditis elegans c fat-1 gene encoding an omega-3 fatty acid desaturase that converts omega-6 to omega-3 fatty acids and the gene is absent in mammals. In this study, researchers successful product the embryo of fat-1 transgenic simmental crossbred cattle using OSM. The results of Western Blotting and fluoroscopic examination have proved that the fat-1 gene has been into genome of clone embryo and translated into proteins which could be used to embryo transfer.
  Jian Wang , Long-yun Kang and Bing-Gang Cao
  This study proposed a new energy control strategy for a distributed power generation system based on renewable. A mathematical model of the system was built based on a vector-controlled induction machine driving a flywheel. The BP Neural network control method was designed in the system in order to regulate DC Bus voltage, which is the object of the system. The experimental results on a wind simulator and flywheel based system verified that proposed energy complementary control can satisfactorily regulate the power of the storage unit to store and release energy and thus to maintain a steady DC voltage from the distributed power generation system.
  Jian Wang
  The reliance of electrical equipment depends to a great extent on its insulation. This study has proposed a remote on-line system to monitor the insulation of capacitive equipment. The system adopts an adaptive algorithm based on multiple sampling and a clustering algorithm based on weighted average grey relational analysis is applied to solve the value of dielectric loss (tanδ) which is the primary parameter in assessing insulation. The system involves a three-layer distributed architecture with two working modes of active query and interruption woken up. DSP is used as the data collection controller on the bottom layer; Zigbee and GPRS ensures communication within the system. The upper monitoring center is capable of data monitoring, analyzing, diagnosing and report generating. The test results show that the system has high accuracy and satisfying synchronization.
  Paul N. Durrington , Valentine Charlton-Menys , Christopher J. Packard , Muriel J. Caslake , Jian Wang , Deepak Bhatnagar , John Scott and Robert A. Hegele
 

Background

Familial hypobetalipoproteinemia (FHBL) is a co-dominant disorder associated with low circulating levels of low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (ApoB). A proband was identified in whom the condition was due to an E110X mutation of APOB, creating a particularly early truncation of ApoB in the region of the molecule necessary for very-low-density lipoprotein (VLDL) assembly. The mutation was also associated with nonalcoholic fatty liver disease.

Objective

To assess the effect of the mutation on metabolism and the formation of VLDL and LDL subfractions.

Results

Both the proband and his son, who had the same mutation, had low LDL cholesterol and decreased ApoB, but an increased small-dense LDL level. Lipoprotein profiles were normal in the proband's sister and grandson, in whom the mutation was absent. In the proband. there was a profoundly diminished rate of production of VLDL-2. VLDL-1 production, however, was relatively preserved and, because of its decreased catabolism, its pool size was increased. Direct formation of intermediate-density lipoprotein (IDL) and LDL was undetectable. Intermediate-density lipoprotein catabolism was greatly increased and its conversion to LDL was increased. The LDL produced was entirely small-dense LDL. High-density lipoprotein cholesterol levels were low, perhaps also related to the relative increase in VLDL-1, which is an avid acceptor of cholesteryl ester.

Conclusions

This novel mutation provides evidence to support the hypothesis that hepatic production of large VLDL-1 leads to the creation of small-dense LDL.

  Handrean Soran , Valentine Charlton-Menys , Robert Hegele , Jian Wang , Emyr W. Benbow , Ian Roberts , Grahame Wood and Paul Durrington
  Not available
  Juan Tan , Wentao Qiao , Jian Wang , Fengwen Xu , Yue Li , Jun Zhou , Qimin Chen and Yunqi Geng
  Interferon-induced proteins (IFPs) exert multiple functions corresponding to diverse interferon signals. However, the intracellular functions of many IFPs are not fully characterized. Here, we report that IFP35, a member of the IFP family with a molecular mass of 35 kDa, can interact with the bovine Tas (BTas) regulatory protein of bovine foamy virus (BFV). The interaction involves NID2 (IFP35/Nmi homology domain) of IFP35 and the central domain of BTas. The overexpression of IFP35 disturbs the ability of BTas to activate viral-gene transcription and inhibits viral replication. The depletion of endogenous IFP35 by interfering RNA can promote the activation of BFV, suggesting an inhibitory function of IFP35 in viral-gene expression. In addition, IFP35 can interact with the homologous regulatory protein of prototype FV and arrest viral replication and repress viral transcription. Our study suggests that IFP35 may represent a novel pathway of interferon-mediated antiviral activity in host organisms that plays a role in the maintenance of FV latency.
  Jian Wang , Lei Wang , Yu Zeng , Yu-Qing Fang , Qin Zhang and Yinghan Wang
  The alignment of nematic liquid crystals by rubbed polyimide surfaces has been well-studied and developed. A novel polyimide film which induced a homeotropic alignment of the nematic liquid crystal without rubbing or with weak rubbing strength was presented. However, there was a transition from homeotropic to planar alignment of the nematic liquid crystal after strong rubbing. In order to study the transition, the polyimide surface was investigated by atomic force microscopy, surface free energy measurement and angle-resolved analysis X-ray photo-electron spectroscopy before and after rubbing with a velvet fabric. It was found that both the change of surface polarity and surface morphology were not the reasons for the transition. The droop of the side chain on the polyimide surface after the rubbing treatment was detected by angle-resolved analysis X-ray photo-electron spectroscopy. Owing to the special structure of the novel polyimide, the X-ray photo-electron spectroscopy was successfully used for the first time to analyse the conformational change of the side chain of a polymer. In conclusion, the transition of nematic liquid crystal alignment from homeotropic to planar after rubbing was influenced by the side chain conformation of the polyimide.
  Shi-Biao BAI , Jian WANG , Guo-Nian LU , Ping-Gen ZHOU , Sheng-Shan HOU and Su-Ning XU
  A detailed landslide-susceptibility map was produced using a data-driven objective bivariate analysis method with datasets developed for a geographic information system (GIS). Known as one of the most landslide-prone areas in China, the Zhongxian-Shizhu Segment in the Three Gorges Reservoir region of China was selected as a suitable case because of the frequency and distribution of landslides. The site covered an area of 260.93 km2 with a landslide area of 5.32 km2. Four data domains were used in this study, including remote sensing products, thematic maps, geological maps, and topographical maps, all with 25 m × 25 m pixels. Statistical relationships for landslide susceptibility were developed using landslide and landslide causative factor databases. All continuous variables were converted to categorical variables according to the percentile divisions of seed cells, and the corresponding class weight values were calculated and summed to create the susceptibility map. According to the map, 3.6% of the study area was identified as high-susceptibility. Extremely low-, very low-, low-, and medium-susceptibility zones covered 19.66%, 31.69%, 27.95%, and 17.1% of the area, respectively. The high- and medium-hazardous zones are along both sides of the Yangtze River, being in agreement with the actual distribution of landslides.
  Su Yeon Shim , Benjamin Adam Samuels , Jian Wang , Gernot Neumayer , Camille Belzil , Ramses Ayala , Yang Shi , Yujiang Shi , Li-Huei Tsai and Minh Dang Nguyen
  Ndel1, the mammalian homologue of the Aspergillus nidulans NudE, is emergently viewed as an integrator of the cytoskeleton. By regulating the dynamics of microtubules and assembly of neuronal intermediate filaments (IFs), Ndel1 promotes neurite outgrowth, neuronal migration, and cell integrity (1–6). To further understand the roles of Ndel1 in cytoskeletal dynamics, we performed a tandem affinity purification of Ndel1-interacting proteins. We isolated a novel Ndel1 molecular complex composed of the IF vimentin, the molecular motor dynein, the lissencephaly protein Lis1, and the cis-Golgi-associated protein αCOP. Ndel1 promotes the interaction between Lis1, αCOP, and the vimentin-dynein complex. The functional result of this complex is activation of dynein-mediated transport of vimentin. A loss of Ndel1 functions by RNA interference fails to incorporate Lis1/αCOP in the complex, reduces the transport of vimentin, and culminates in IF accumulations and altered neuritogenesis. Our findings reveal a novel regulatory mechanism of vimentin transport during neurite extension that may have implications in diseases featuring transport/trafficking defects and impaired regeneration.
  Ming-Xiang Zhang , Cheng Zhang , Ying H. Shen , Jian Wang , Xiao Nan Li , Yun Zhang , Joseph Coselli and Xing Li Wang
  Endothelial nitric-oxide synthase (eNOS) is a constitutively expressed gene in endothelium that produces NO and is critical for vascular integrity. Previously, we reported that the 27-nucleotide (nt) repeat polymorphism in eNOS intron 4, a source of 27-nt small RNA, which inhibits eNOS expression, were associated with cardiovascular risk and expression of the eNOS gene. In the current study, we investigated the biogenesis of the intron 4-derived 27-nt small RNA. Using Northern blot, we showed that the eNOS-derived 27-nt short intronic repeat RNA (sir-RNA) expressed only in the eNOS expressing endothelial cells. Cells containing 10 x 27- or 5 x 27-nt repeats produced higher levels of 27nt sir-RNA and lower levels of eNOS mRNA than the cells with 4 x 27-nt repeats. The 27nt sir-RNA was mostly present within the endothelial nuclei. When the splicing junctions of the 27-nt repeat containing intron 4 in the full-length eNOS cDNA vector were mutated, 27nt sir-RNA biogenesis was abolished. Suppression of Drosha or Dicer diminished the biogenesis of the 27nt sir-RNA. Our study suggests that the 27nt sir-RNA derived through eNOS pre-mRNA splicing may represent a new class of small RNA. The more eNOS is transcribed or higher number of the 27-nt repeats, the more 27nt sir-RNA is produced, which functions as a negative feedback self-regulator by specifically inhibiting the host gene eNOS expression. This novel molecular model may be responsible for quantitative differences between individuals carrying different numbers of the polymorphic repeats hence the cardiovascular risk.
 
 
 
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