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Articles by Jemal Hussien
Total Records ( 4 ) for Jemal Hussien
  Jemal Hussien , Kaba Urgessa , Fayissa Regassa , Awol Jemal , Sultan Abajebel and Nezif Hussien
  The present study was aimed at investigating the antihelmentic effects of the essential oil extracts of Coriandrum sativum Linn., Ocimum gratissimum Linn., Ocimum lamifolium Hochst. ex Benth, Ruta chalpensis Linn., Thymus schimperi Ronniger and Echinops kebericho Mesfin against H. contortus. In vitro bioassay employing the egg hatching test was conducted to determine the antihelmentic potential of the essential oils at 1, 0.5, 0.25, 0.125 and 0.0625% (v/v) concentration. The concentration of the extracts that inhibited 50% of test organisms (IC50) was determined using probit analysis of the mean percent egg hatch inhibition followed by linear regression analysis. Accordingly, the plants demonstrated inhibitory effects on hatching of eggs at all concentration levels. The mean percent inhibition at 1% conctration ranged from 81.8±0.6 (E. kebericho) to 100±0 (O. gratissimum and R. chalpensis). At each test concentration of the essential oils, the observed biological effect was statistically significant (p<0.05). Among the extracts, the essential oils of O. gratissimum (IC50 0.0784% v/v), R. chalpensis leaf (IC50 0.0876% v/v) and fruit (IC50 0.0944% v/v) were found to be the most active against H. contortus egg hatching. The intensity of egg hatching inhibitory effect of the essential oils was observed to vary in a dose dependent fashion (p<0.05) and 1% concentration of the essential oils of most of the plants investigated was generally best efficacious with comparable efficacy to the positive antihelmentic compound, thiabendazole (0.5 μg mL-1). The result indicated the potential utility of the plants in the control of egg shedding into the environment to prevent infection of new hosts during grazing. In vivo antihelmentic efficacy and toxicity studies of the plants should be established.
  Jemal Hussien , Chalachew Teshale and Jemal Mohammed
  The objective of the present study was to evaluate the in vitro antimicrobial effects of the hydrosols of basil (O. basilicum), thyme (T. schimperi), cardamon (E. cardamom), cinnamon (C. Zeylanicum), mustard (B. nigra) and clove (S. aromaticum) against S. aureus, E. coli, S. typhi, P. aerugenosa and Candida albicans. Hydrosols were obtained from the selected plant species after hydro distillation using Clevenger type apparatus. The antimicrobial effects of the hydrosols were determined by measuring the zone of microbial growth on agar plates treated with hydrosol and control agar (hydrosol untreated agar) plates and then the percentage of growth inhibition was determined. Accordingly, the percent inhibition of the hydrosols were found to range from 20 to 100% (against S. aureus, p = 0.005), 10 to 100% (against E. coli, p = 0.005), 0 to 35% (against P. aerugenosa, p = 0.069) and 15 to 100% S. typhi, p = 0.00). Complete (100%) growth inhibition was demonstrated at 15% hydrosol concentration of cardamom and thyme (against E. coli), cardamon and cinnamon (against S. aureus) and cardamom, thyme and cinnamon (against S. typhi). Candida albicans were inactive to the test hydrosols. From this study, it can be concluded that the hydrosols of basil, cardamom, clove, cinnamon and thyme were effective to elicit inhibitory effect against S. typhi, S. aureus and E. coli. Further study is recommended to verify the activity of the plant hydrosols against wide range of microbial strains, characterize the chemical constituents of the hydrosols and see if the biological property can be correlated to the constituents.
  Tariku Sori , Jemal Hussien and Molalegne Bitew
  Cross sectional experimental study was conducted to assess the prevalence and susceptibility pattern of Staphylococcus aureus isolated from bovine mastitis to commonly used antibacterial agents in Jimma town dairy farms, South West Ethiopia from January-July, 2010. Milk samples were collected aseptically and California Mastitis Test (CMT) was carried out to identify subclinical mastitis from dairy cows. All CMT high scored and clinically positive samples were investigated microbiologically. Rate of isolation of Staphylococcus aureus was determined and susceptibility of 11 antibiotics against S. aureus was evaluated using the Kirby-Bauer disc diffusion method and the result was expressed as sensitive, intermediate and resistant. From total of 218 milk samples collected, 164 CMT high score milk samples were cultured of which 86 (52.4%) of pure strains of S. aureus were isolated. Out of 86 pure isolates of S. aureus resistance was detected for Penicillin (87.2%), Nalidixic acid (92%), Amoxicillin (46%), Chloramphenicol (16%), Clindamycin (4%) and Vancomycin (3%). The study also revealed that S. aureus was found to be sensitive for Norfloxacilin, Gentamycin, Tetracycline and Bacitracin. The present finding indicates that these isolates exhibited the highest degree of resistance to Nalidicic Acid, Penicillin, Amoxicillin and Chloramphenicol of among the tested anti microbial agents in comparison to previous studies reported. Furthermore, resistance follow-up, appropriate selection and use of antibiotic is recommended in the treatment of mastitis.
  Gebrehiwot Teklay , Jemal Hussien and Dawit Tesfaye
  Treatment non-adherence for chronic illnesses such as diabetes is a common problem. The aim of the study was to assess the pattern of non-adherence to diabetic therapy and associated factors among type 2 diabetic patients. A cross sectional study was conducted from February 01 to April 30, 2011, at Jimma University Specialized Hospital diabetic clinic. Data on Socio-demographic characteristics, disease related and medication related factors, complexity of regimen and drug side effects were collected. Medication non-adherence was measured using a self-reported 4-item Morisky scale. Patient characteristics, number and dosing of all prescribed medications, glycemic control levels, diabetes related complications, co-morbid conditions and diabetes related admissions were reviewed from patient records. Univariate and multivariate logistic regression model was used to identify the factors related to non-adherence. Among the total of 267 type 2 diabetic patients (mean age 52.4±11.9), the prevalence of non-adherence was 24.3% (n = 267). About half of the patients 140 (52.4%) were on Metformin/Glibenclamide based combination therapy. Patients with depressive symptoms (AOR = 2.404, 95% CI = 1.323-4.366, p = 0.004) and who experienced side effects (AOR = 1.868, 95% CI = 1.012-3.446, p = 0.046) were twice more likely to be non adherent than without depressive symptoms and without manifesting side effects, respectively. Similarly, diabetic patients on complex regimen were three times non adherent (AOR = 3.413, 95% CI = 1.652-7.050, p = 0.001) than those with simple regimen. In conclusion, non-adherence in the current study was high particularly among patients with depressive symptoms, side effects and on complex regimen. Thus, continuous adherence monitoring and support services need to be implemented to such group of patients.
 
 
 
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