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Articles by Jean Koudou
Total Records ( 2 ) for Jean Koudou
  C. Zongo , Etienne-Francois O. Akomo , A. Savadogo , Louis Clement Obame , Jean Koudou and Alfred S. Traore
  The antimicrobial activity of the total alkaloids from the leaves of Mitragyna inermis (Willd.) O. Kuntze (Rubiaceae) From Burkina Faso was evaluated using disc diffusion essay and broth microdilution assay. The extract was used against ten (10) reference bacterial strains and three (3) clinical isolates including Gram(+) and Gram(-) strains. The alkaloids showed moderate activity against mcroorganisms tested. The highest Diameter of Inhibition Zone (DIZ) was obtained with S. aureus ATCC9244 (23 ± 1 mm). The lowest Minimum Inhibitory Concentration (MIC) obtained was 0.625 mg mL-1 recorded with three (3) Gram(+) bacteria (S. aureus ATCC 25293, S. aureus (clinical isolate) and S. carmorum LMG 13567) and one Gram(-) strain (P. mirabilis CIP104588. Results showed that Gram(+) bacteria are more sensitive to alkaloids from M. inermis than Gram(-) bacteria. This study confirmed the use of the plant in traditional medicine against some infectious diseases.
  Abdel Magid Ouoba , Noya Some , Jean Koudou , Sylvin Ouedraogo and Innocent Pierre Guissou
  The main goal of this study was to determine the acute toxicity and irritancy of the leaf of essential oil of Vitex simplicifolia Oliv. (Verbenaceae) growing in Burkina Faso and whose therapeutic use is multiple. The acute toxicity of the essential oil was determined by Litchfield method. Skin and eye irritancy was performed by Draize method. The acute toxicity of essential oil was evaluated to give a LD50 = 2830.77±299.22 mg kg-1 and showed that the essential oil of Vitex simplicifolia is slightly toxic. Skin and eye irritation was evaluated and showed that essential oil of this plant is slightly irritating with a primary irritation index PI = TEO/16 = 0.75, an Acute Ocular Index, Ac.O.I. =12.83, an Average Ocular Index, Av.O.I. of less than 5 after 48 h. The results suggest that the leaf essential oil of Vitex simplicifolia Oliv. possessed slightly toxic and slightly irritancy activities. It could be used as natural potential ingredient for pharmaceutical industry.
 
 
 
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