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The antimicrobial activity of the total alkaloids from
the leaves of Mitragyna inermis (Willd.) O. Kuntze (Rubiaceae)
From Burkina Faso was evaluated using disc diffusion essay and broth microdilution
assay. The extract was used against ten (10) reference bacterial strains
and three (3) clinical isolates including Gram(+) and Gram(-) strains.
The alkaloids showed moderate activity against mcroorganisms tested. The
highest Diameter of Inhibition Zone (DIZ) was obtained with S. aureus
ATCC9244 (23 ± 1 mm). The lowest Minimum Inhibitory Concentration
(MIC) obtained was 0.625 mg mL-1 recorded with three (3) Gram(+)
bacteria (S. aureus ATCC 25293, S. aureus (clinical isolate)
and S. carmorum LMG 13567) and one Gram(-) strain (P.
mirabilis CIP104588. Results showed that Gram(+) bacteria are more
sensitive to alkaloids from M. inermis than Gram(-) bacteria. This
study confirmed the use of the plant in traditional medicine against some
infectious diseases.
The main goal of this study was to determine the acute toxicity and irritancy
of the leaf of essential oil of Vitex simplicifolia Oliv. (Verbenaceae)
growing in Burkina Faso and whose therapeutic use is multiple. The acute toxicity
of the essential oil was determined by Litchfield method. Skin and eye irritancy
was performed by Draize method. The acute toxicity of essential oil was evaluated
to give a LD50 = 2830.77±299.22 mg kg-1 and showed
that the essential oil of Vitex simplicifolia is slightly toxic. Skin
and eye irritation was evaluated and showed that essential oil of this plant
is slightly irritating with a primary irritation index PI = TEO/16 = 0.75, an
Acute Ocular Index, Ac.O.I. =12.83, an Average Ocular Index, Av.O.I.
of less than 5 after 48 h. The results suggest that the leaf essential oil of
Vitex simplicifolia Oliv. possessed slightly toxic and slightly irritancy
activities. It could be used as natural potential ingredient for pharmaceutical
industry.
