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Articles by Jean Paul Kamdem
Total Records ( 2 ) for Jean Paul Kamdem
  Wasim Ahmad , Mushtaq Ahmad , Rahmat Ali Khan , Nadia Mushtaq , Jean Paul Kamdem and Joao Batista Teixeira da Rocha
  Background and Objective: Ischemia is a stern decline or absolute obstruction in blood, flowing to various parts of the body. This pathophysiological episode causes cerebral mutilation, a protuberant feature of stroke, which is the 3rd leading cause of demise after cancer and heart attack globally. The principal objective of this work was to understand the sights of neuroprotection provided by M. Officinalis against OGD-R in rat’s brain cortex slices. Materials and Methods: Mitochondrial viability assays were performed via the colorimetric 3(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method. After 2 h of oxygen and glucose deprivation (OGD) followed by 1 h of reperfusion, only viable slices showed the ability to trim down MTT into a purple "Formazan" product that was soluble in dimethyl sulfoxide (DMSO). Absorbance was measured at 570 and 630 nm and the net absorbance (A570-A630) was taken as an index of cell viability. Results: The results of the present investigation demonstrated that oxygen-glucose deprivation (OGD) followed by re-oxygenation led to cell damage/death via an amplifying ROS/free radicals production in rat’s brain cortex slices compared with control after 2 h OGD followed by 1h reperfusion. Melissa officinalis at a concentration of 40 μg mL–1 displayed potential role in neuro-protection against OGD, followed by re-oxygenation in mitochondrial viability assays in vitro. In addition, Melissa officinalis declined or slow down the production of free radicals in the supernatant and slices homogenate of cortex at the end of 2 h OGD followed by 1 h reperfusion. Furthermore, higher concentrations of Melissa officinalis slightly showed neurotoxicity for cortex slices which might be attributed to its pro-oxidant outcome. Conclusion: The results obtained during this study offer evidence for neuroprotective properties of M. officinalis against in vitro ischemia in rat’s cortex slices. Melissa officinalis could be considered as a therapeutic agent in the prevention of neuronal cell death in Ischemia induced by oxygen and glucose deprivation of cortex slices, strengthening further investigations to define the actual component for its use in human. Furthermore, in vivo ischemic models are now in progress to confirm and better characterize its neuroprotection.
  Gerlania de Oliveira Leite , Albys Ferrer Dubois , Rodrigo Lopes Seeger , Aline Augusti Boligon , Jose Galberto Martins da Costa , Thiago Henrique Lugokenski , Adriana Rolim Campos , Roselei Fachinetto , Jean Paul Kamdem , Joao Batista Teixeira da Rocha and Caroline Wagner
  Background and Objective: Vanillosmopsis arborea Baker (candeeiro) is a native plant from the Northeast of Brazil. Recently, this plant attracted interest of researchers due to its pharmacological properties, however, there is no underling mechanism established for its properties. So, the aim of this study was to investigate the antioxidant potential of this plant, since oxidative stress is in the core of the development of the diseases that V. arborea shows to be efficient in counteract. Materials and Methods: For this purpose, used aqueous extracts from bark, trunk and leaves for the plant, as well as the essential oil from the truck, in a set of oxidative stress models. Results: The main results obtained here demonstrate that aqueous extract from leaves are able to reduce Fe(II)-induced lipid peroxidation. However, when tested for iron chelation, none of the extracts shows any effect. For this reason, performed free radical scavenging test, by the quenching of 1’1’-diphenil-2-picrylhydrazyl (DPPH). It was observed that both aqueous extract from leaves and essential oil from the trunk were capable to scavenge free radical, indicating a direct effect of the plant on free radicals. Due to high (-)-α-bisabolol content in the essential oil and in the aqueous extract from leaves, hypothesized that this compound could be a central character in the antioxidant activity of the plant. So, performed a 2’7’-dichlorodihydrofluorescein diacetate (DCFH-DA) oxidation test with the essential oil and the (-)-α-bisabolol, which confirm the suggestion that (-)-α-bisabolol could be a major responsible for the antioxidant activity of V. arborea. Conclusion: Thus, V. arborea Baker could be considered an effective agent in the prevention of various diseases associated with oxidative stress and (-)-α-bisabolol is suggested to have prominent role in the plant properties.
 
 
 
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