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Articles by Jasbir Singh
Total Records ( 6 ) for Jasbir Singh
  Rupinderjeet Kaur , Amandeep Singh , Jasbir Singh and Rimpi Bansal
  Cysticercosis is a common disease in developing countries, occurs when man is infested by the larvae of Taenia solium, acting as an intermediate host instead of definitive. The affected sites include cerebral tissue, ocular organs and muscles. Oral cysticercosis is a rare event and it represents a difficulty in clinical diagnosis. Diagnosis is usually made on microscopic examination. Following is a case report of a 50 years old male, who reported to our centre with a swelling in the inner aspect of angle of mouth, which was diagnosed as cysticercosis on histopathology.
  Jasbir Singh , Harmeet Kaur , Aditi Kaushik and Sapna Peer
  The principle of antisense technologies is based on the specific inhibition of unwanted gene expression by blocking mRNA activity. It has long appeared to be an ideal strategy to leverage new genomic knowledge for drug discovery and development. During the past 20 years the technology associated with the development of antisense has improved dramatically and emerging chemistries have made antisense oligonucleotides into powerful and versatile tools to study the function of proteins in living cells. In recent years, antisense technologies have been widely used as potent and promising tools for this purpose. There is a rapid increase in the number of antisense molecules progressing in clinical trials. Antisense technologies provide a simple and efficient approach for drug discovery and development and are expected to become a reality in the near future.
  Jasbir Singh , Harmeet Kaur and Sunil Gupta
  The study was oriented towards development of analytical method and prediction of real relationship between absorbance and concentration variables while conforming to validation parameters. Seven compositions, A1, A2, A3, B1, B2, B3, C containing different ratios of model drug (ofloxacin) and polymers (HPMC and sodium alginate) were used to prepare ofloxacin composition solutions of 5 μg mL-1 in Simulated Gastric Fluid (SGF, pH 1.2), buffer (pH 6.2) and Simulated Intestinal Fluid (SIF, pH 7.5). Similarly, ofloxacin solutions of 2, 4, 5, 6 and 8 μg mL-1 were also prepared. The method was assessed with respect to (w.r.t.) all requisite principle parameters like specificity, precision, range and inter/intra-day variations alongwith linearity/non-linearity (model generation) and balancing of the variance at various concentration levels. The specificity was notified from constant absorbance and non-shifting absorbance wavelength maxima (λmax) of unspiked and spiked samples. The RSD value <5.0% for absorbance readings of various samples, prepared at different times, expressed the precision and inter/intra-day variations within the limits. The absorbance values within 0.2-0.8 for 2-8 μg mL-1 concentrations in different media satisfied the concentration range for analysis. For standard plots, equation yi = β1Xi+ei (Model 2 or equation 3) was sorted as final equation on basis of model selection scheme (Scheme 1). For balancing variance, weight=1/conc.2 was found best on basis of weight selection scheme (Scheme 2). The classical approach predicted the real relationship between concentration and absorbance values and can be applied similarly to other spectroscopic techniques for analytical methods development.
  Himanshu Aggarwal , Alka Rao , J.S. Rana , Jasbir Singh , Anil Kumar , Vinod Chhokar and Vikas Beniwal
  The present investigation was carried out to access the suitability and reliability of ISSR analysis for inferring genetic diversity among chickpea genotypes. A total of six ISSR markers were used to study genetic diversity among 115 genotypes of chickpea. Out of six ISSR markers (GTGC)4 (GTG)5 and (TCC)5 were found to generate reproducible DNA fragments of size ranging from 0.15-3, 0.40-2.5 and 0.35-2 kb and yielded 2-9, 3-10 and 4-11 number of fragments, respectively. Clustering analysis separated all the genotypes into five genetically similar groups. The value of cophenetic correlation coefficient (r) is 0.91 which is considered as a good fit. The genetic similarity coefficient among 115 chickpea genotypes ranged from 0.01 to 0.90. These values indicated high genetic variability among chickpea cultivars and can be used efficiently for gene tagging and genome mapping of crosses to introgress the favourable traits such as high yield potential, disease and insect resistance into the cultivated genotypes.
  Tejinder Pal Khaket , Himanshu Aggarwal , Drukshakshi Jodha , Suman Dhanda and Jasbir Singh
  Parthenium hysterophorus is an aggressive weed being invasive with allelopathic effect, it poses a serious threat to the environment and biodiversity. It adversely affects grazing animals and human beings, which directly or indirectly comes in contact with this weed. All ways to control it are not fully successful. However, recent reports suggest its medicinal uses as antidiabetic, antioxidant, antitumor and antimalarial which can be explored for human use after scientific trials. It is also a rich source of minerals like N, P, K, Fe, Mn, Cu and Zn which also makes it useful for agriculture. Uprooted Parthenium before fruiting can be used as easily available, cheap and nutrient rich compost. Parthenium can also be used as a potent herbicide, insecticide, pesticide and phytoremedial agent for metal and dye removal from industrial waste. As, Parthenium has various beneficial and harmful effects so, it should be used after thorough research.
  Jasbir Singh , Gajendra Singh , Nirpinder Singh and Harmeet Kaur
  The aim of the research was to study the potential of various grades of hydroxypropylmethyl cellulose (HPMC) in enhancing oral bioavailability of insulin. Enteric coated HPMC-insulin granules (HPMC-insulin granules), enteric coated control granules (control granules or placebo) of only HPMC and control (peroral) solution of zinc insulin in glycerine IP were tested in vivo in rats. An assay value of 99.6±1.6% of HPMC-insulin granules confirmed the minimal insulin degradation during granulation/coating process. In vivo studies showed maximum blood glucose lowering with K100LV-insulin granules corresponding to a relative pharmacological efficacy of 1.399±0.138% and absolute pharmacological efficacy of 0.537±0.059%. In contrast, neither control granules nor control (peroral) solution showed a comparable effect. The multiple comparison post-hoc test, LSD (p-level of 0.05), showed a significant difference of K100LV, E50LV, E5LV, E4M-insulin granules from control (untreated) and of only K100LV, E50LV-insulin granules from control (peroral) solution on grades vs. controls basis. On grades vs. grades basis, the potential of HPMCs in lowering of blood glucose levels was finalized as K100LV>E50LV>E5LV≅E4M> K4M>K100M. It is concluded that low viscosity grades of HPMC are efficient in enhancing oral insulin absorption as compared to very low and high viscosity grades. However, viscosity appears to mask effect of substitution ratio on insulin absorption.
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