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Articles by Jamila S. Al-Malki
Total Records ( 2 ) for Jamila S. Al-Malki
  Magda M. Sanad , Jamila S. Al-Malki and Areej G. Al-Ghabban
  Schistosomiasis is a parasitic disease causing serious chronic morbidity in tropical countries. Even though an effective treatment exists, it does not prevent re-infection and the development of an effective vaccine still remains the most desirable means of control for this disease. The possible applicability of immunization with a partially purified Soluble Egg Antigen (SEA, 100-137 kDa) for protection against Schistosoma mansoni infection in challenged mice was evaluated by histological and immunohistochemical studying of schistosomula-associated inflammatory reactions and deposition of schistosomal antigens in lung tissues. Schistosomula and inflammatory foci were counted in lung sections by histologic scoring for 25 days Post-Infection (PI). In control non-immunized mice, schistosomula number reached its peak earlier (day 7), decreased rapidly and worms were barely detectable on day 25. In immunized mice, the number reached its peak later (day 9), decreased gradually and many worms were still retained in the lungs until day 25. Mild pulmonary cellular reaction was noticed in control mice while in immunized ones, evident mononuclear cellular infiltration with inflammatory foci appeared earlier (day 7) and significantly increased on subsequent days and was most probably of Delayed Type Hypersensitivity (DTH). Schistosomal antigen deposition in lung tissues was markedly augmented in immunized mice. The present study indicates that immunization with this SEA caused augmentative pulmonary response against challenge infection, represented by inducing anamnestic inflammation in lung tissues with consequent blocking of migration of lung schistosomula and more deposition of schistosomal antigens with more stimulation of the immune response. So, this type of antigen may be useful for the composition of a vaccine against schistosomiasis.
  Jamila S. Al-Malki and Rania S. Rashwan
  Background and Objective: The head lice, Pediculus humanus capitis is considered one of the most important parasites that attach human body and causes many diseases infestation of humans worldwide. This insect could be found between children during the warm months in developed and developing countries. This study is aimed to evaluate the insecticidal effect of wood tar oil against the adult of head Lice Pediculus humanus capitis. Materials and Methods: Adult insects were collected from school children that do not have been treated with any applications whether chemical or natural treatments. Adult insects were treated with 3, 5 and 7% of wood tar. Acetylcolinesterase, glutathione peroxidase and superoxide dismutase activities were evaluated. In addition, total soluble protein in treated insects was quantified using Bradford technique. Alterations in adult insects were evaluated using scanning electron microscope. Results: Observed data demonstrated significant effect of three concentrations 3, 5 and 7% of wood tar where the recorded mortalities were 60, 90 and 100% after 6 h, respectively. Treatments with wood tar caused inhibition in acetylcholine esterase level, it also reduces the total protein activity in treated insects. The GPX and SOD activities increased gradually in the adult of P. humanus capitis after exposure with tar concentrations. Scanning electron microscope showed several distortions of the body structure, spiracles, hairs and body segments of dead lice exposed to wood tar. Conclusion: Treatment with tar caused oxidative and morphological damages in insects. Wood tar could be a good insecticidal agent against head Lice Pediculus humanus capitis.
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