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Articles by Jain Dilpesha
Total Records ( 1 ) for Jain Dilpesha
  Somani Rahul , Khalate Vinay , Jain Dilpesha and Singhai Abhay Kumar
  Background: Diabetic individuals are at greater risk of developing comorbid depression independent of the type of diabetes. Approximately 30% of patients with type 1 or type 2 diabetes are suffering from depression. Materials and Methods: In the present study, the antidepressant activity of herbal formulation Karnim (HFK 200 and 400 mg kg-1, p.o.) was evaluated using locomotor activity, forced swim test, monoamine oxidase (MAO) levels and antioxidant enzymes (MDA, NO, SOD, GSH, CAT) in STZ-induced diabetic rats. The diabetic rats exhibited prolong immobility duration, decreased locomotor activity, increased MAO activity and oxidative stress as compared to normal control rats. Results: Treatment with HFK significantly reduced the immobility period, decreased MAO levels and reduced oxidative stress. However, HFK could not alter the locomotor activity as compared to diabetic control rats. Conclusion: The results of our study indicated that HFK has the potential to be employed as a therapy for depression associated with diabetes.
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