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Articles by J.T. Shu
Total Records ( 2 ) for J.T. Shu
  X.S. Wu , W.B. Bao , J.T. Shu , Q. Xu , X.Y. Zhang , W. Han and G.H. Chen
  This study was designed to investigate the effect of Adenylosuccinate Lyase (ADSL) gene on Inosine Monophosphate content (IMP) in chicken. The chickens used for the study included exogenous Recessive White chicken and Chinese indigenous chicken breeds such as Silkies, Baier, Tibetan and Xiaoshan chickens. A pair of primer was designed to detect exon 2 of ADSL gene by PCR-SSCP and mutation detected was directly sequenced. A synonymous mutation at 3484 bp in exon 2 was substituted C/T SNP. In five chicken breeds, three genotypes TT, CT and CC were observed in exon 2. Muscle IMP content of individuals with TT genotype in exon 2 had significantly higher than those with CT and CC genotypes (p<0.05). In exon 2, Recessive White, Xiaoshan and Baier chickens were in Hardy-Weinberg equilibrium (p>0.05) and Silkies and Tibetan chickens were significant departure from Hardy-Weinberg equilibrium (p<0.01).
  Y.F. Zhu , H.F. Li , W. Han , J.T. Shu , W.T. Song , X.Y. Zhang and K.W. Chen
  The objective of this study was to trace the route of avian Mx (myxo-virus resistance) gene evolution and knowledge of its structure and function variations. Mx gene cDNA sequences of six galliform and anseriform avians were used in this study. Datamonkey and DAMBE were used to detect recombination events and test nucleotide substitution saturation. PAML4b were used to test the selective pressure on amino acid sites. Saturation test did not indicate any sign of substitution saturation. Single breakpoint scanning and genetic algorithm scanning by Datamonkey found two breakpoints, located, respectively in 162 and 999 bp and divided the sequences into three nonrecombination split partitions. The selection test of site-specific mode showed that avian Mx gene sequences had suffered positive selection pressure. Likelihood Ratio Test (LTR) suggested M2a and M8 be more advantageous models,and in a total of eight positive sites with >95% posterior probability were identified in three nonrecombination split partitions. These detected positive sites distributed in N-ternimal and GTP-binding domain of Mx protein and might be important candidate marks for improving avian antiviral activity.
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